DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and spg7

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_001923118.1	Gene:	spg7 / 794740	ZFINID:	ZDB-GENE-030131-5391	Length:	788	Species:	Danio rerio

Alignment Length:	760	Identity:	243/760 - (31%)
Similarity:	372/760 - (48%)	Gaps:	130/760 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TTHSVPYLYLGNFSRKPHYYSVNRTKLHGSAGAARLSKSTSTSSRSHDLVLDLRNLLSRSSASIQ 69
            ||.:..:..||:    .||:|.:..|.....|....:.......:            .|.....|
Zfish    79 TTQAKLWKLLGS----THYFSTSNRKHENKQGGKGKTPEEEEEEK------------KRREQEDQ 127

  Fly    70 GMVERAARLNGILDRRLVDDVLAKVTSMLPSMRDVRVTLEESATQIGRVQLQNYQFEVSLTGAAG 134
            ...||...|          .::|.:.|:|.|:.          |..|.:...::..|:.   |.|
Zfish   128 MYRERLRTL----------FIIAVIMSLLNSIN----------TSGGNISWNDFVNEML---AKG 169

  Fly   135 SVPTGANVKVIPT-------ITPGLL---RP---LFSQQQLNQIRGFKTDRSIEAEQKRNPTMTS 186
            .|   :.|:|:|.       :.||.:   ||   |..:.|:..|..|:
Zfish   170 EV---SRVQVVPESDIVEIYLHPGAVIFGRPRLALMYRMQVANIDKFE----------------- 214

  Fly   187 RLKNALANSPQRLDGDTPLQAEKLRRLLAKSEEHGFNKAESLKIAFAE-GYLAAANSEDSPKSGK 250
                                 ||||   |..||...:..:.:.:.:.. |:...|
Zfish   215 ---------------------EKLR---AAEEELNIDAKDRIPVTYKRTGFFGNA---------- 245

  Fly   251 TMKYLKTLQTIVVIVVFLGIFLSFFTTSNG--SVFRSIQLGNQVEVDPEE-INVTFEDVKGCDEA 312
              .|...:..|.|.:::....|:.....:|  |.|..:::.....||.:. ..|:|:||.|..||
Zfish   246 --LYALGMAAIGVAILWYIFRLAGMGGRDGGFSAFNQLKMAKFTIVDGKSGKGVSFKDVAGMREA 308

  Fly   313 KQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVL 377
            |.|:||.|::||:|:::..||.|:|||.||:||||.||||||:|||.||:|||...||.||.||:
Zfish   309 KMEVKEFVDYLKNPDRYLQLGAKVPKGSLLLGPPGCGKTLLAKAVATEAQVPFLAMAGSEFVEVI 373

  Fly   378 VGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLHPYAN----QTINQLLSEMDGFHQN 438
            .|.||.|||.|||.|:|||||:::|||||:||.||:.: :..::|    ||:||||.||||....
Zfish   374 GGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTN-MSGFSNTEEEQTLNQLLVEMDGMGTT 437

  Fly   439 AGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKILHDEIDLDM----LA 499
            ..||||.:|||.|.||.||:||||.|..:.:..|....||||...:| |||......|.    ||
Zfish   438 DHVIVLASTNRADILDNALMRPGRLDRHIFIDLPTLQERKEIFEQHL-KILKLTQPADFYSLRLA 501

  Fly   500 RGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHE 564
            ..|.||:|||:.|:.|:|||.||.:|.:::.....|.|.::|:.|..:|:::..:|...:.|:||
Zfish   502 ELTPGFSGADIANICNEAALHAAREGFKSIDTFSFEYAVERVIAGSVKKSKILSKEEQRVVAFHE 566

  Fly   565 GGHAIVAFYTKESHPLHKVTIMPR-GPSLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELV 628
            .|||:|.:..:.:..:.||:|.|| ..:||....:| ::::..||.||...|...:||||:|.:.
Zfish   567 SGHALVGWLLEHTEAVMKVSIAPRTNAALGFAQILP-RDQFLFTKEQLFERMCMALGGRASEAIT 630

  Fly   629 FGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTI---EASKGLGTGDTLGPNTIEAVDAE 690
            |  :|:|:||..||::.|.:|..||:.:||.|.||..:.   |...|:|. ........:.:|.|
Zfish   631 F--NKVTTGAQDDLRKVTRVAYSMVKQYGMVDSVGQVSFPDSENQSGIGR-RPFSQGLQQQMDLE 692

  Fly   691 IKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAIL 735
            .|.:::.:|...:.:|..:..:...||.|||:.|.::.:||:|:|
Zfish   693 AKMLIAKAYRHTEKLLLDNRDKLILLANALLEREVVNYNDIEALL 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	199/497 (40%)
spg7	XP_001923118.1	FtsH_ext	136..233	CDD:284011	29/163 (18%)
		FtsH_fam	257..738	CDD:273520	196/487 (40%)
		AAA	337..470	CDD:278434	78/133 (59%)
		Peptidase_M41	552..736	CDD:279742	58/187 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820