Protein Alignment YME1L and Afg3l2

DIOPT Version :9

• Sequence 1: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_081406.1
• Gene: Afg3l2 / 69597
• MGIID: 1916847
• Length: 802
• Species: Mus musculus
• Alignment Length: 580
• Identity: 221/580 - (38%)
• Similarity: 322/580 - (55%)
• Gaps: 82/580 - (14%)

  Fly   201 GDTPLQAEKL-----------RRLLAKSEE---HGFNKAESLKIAFAEGYLAAANSEDSPKSGKT 251
            |.||:..:.:           |.|....:|   .|.|:...:.||.::|
Mouse   202 GKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDG---------------- 250

  Fly   252 MKYLKTLQTIVVIVVFL-------------------GIFLSFFTTSNGSVFRSIQLGNQVEVDPE 297
             .:|.::...|:|:.||                   |:|....||:              :|..:
Mouse   251 -SFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTA--------------KVLKD 300

  Fly   298 EINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAK 362
            ||:|.|:||.||:|||.|:.|.|.|||:|:::.:||.|:|||.:|.|||||||||||:|.||||.
Mouse   301 EIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEAN 365

  Fly   363 VPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLHPYANQ--TI 425
            |||...:|.||.|:.||.|..||||||..|:..|||::||||||:||.||........:.|  |:
Mouse   366 VPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTL 430

  Fly   426 NQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKI-L 489
            ||||.|||||:....|::|..|||.|.||.|||||||||.::.:..||..||..|..::|..: |
Mouse   431 NQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKL 495

  Fly   490 HDEIDLDMLARG----TSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKAR 550
            ...::.|.|||.    |.||:|||:.|:.|:|||.||...::.::.||.|.|.::|:.|.|:|.:
Mouse   496 DSALEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDAINEKHFEQAIERVIGGLEKKTQ 560

  Fly   551 LPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQLLAMM 615
            :...|.....||||.|||:..:|.:.:.||.||:|:|||..||:..|:| ||:|..||.|||..|
Mouse   561 VLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLP-KEQYLYTKEQLLDRM 624

  Fly   616 DTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGLGTGDTL- 679
            ...:|||.:||:.||  :||:||..||::.|..|...:..:||::|||..:.:..:   .||.:
Mouse   625 CMTLGGRVSEEIFFG--RITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPR---QGDMVL 684

  Fly   680 ----GPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAIL 735
                ...|...:|.|::.::||:|.|..|:|.:...:.:.:|..||:.|.||.:|:..:|
Mouse   685 EKPYSEATARMIDDEVRILISDAYRRTVALLTEKKADVEKVALLLLEKEVLDKNDMVQLL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	210/513 (41%)
Afg3l2	NP_081406.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..124
		FtsH_ext	145..241	CDD:284011	8/38 (21%)
		FtsH_fam	252..745	CDD:273520	210/513 (41%)
		AAA	344..475	CDD:278434	75/130 (58%)
		Peptidase_M41	561..743	CDD:279742	68/187 (36%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..802

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920