Protein Alignment YME1L and PSMC6

DIOPT Version :10

• Sequence 1: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_002797.4
• Gene: PSMC6 / 5706
• HGNCID: 9553
• Length: 389
• Species: Homo sapiens
• Alignment Length: 374
• Identity: 125/374 - (33%)
• Similarity: 185/374 - (49%)
• Gaps: 70/374 - (18%)

  Fly   202 DTPLQAEKLRRLLAKSEEHGFNK--AESLKIAFAEGYLAAANSEDSPKSGKTMKYLKTLQTIVVI 264
            |..|| :..::||...|..|..|  .|.||             |.:.:..|:...||.||::..|
Human     6 DKALQ-DYRKKLLEHKEIDGRLKELREQLK-------------ELTKQYEKSENDLKALQSVGQI 56

  Fly   265 VVFLGIFLSFFT-------TSNGSVF----------RSIQLGNQVEVD----------PEEI--- 299
            |   |..|...|       .:||..:          ..::.|.:|.:|          |.|:
Human    57 V---GEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKSKLKPGTRVALDMTTLTIMRYLPREVDPL 118

  Fly   300 ----------NVTFEDVKGCDEAKQELKEVVEF-LKSPEKFSNLGGKLPKGVLLVGPPGTGKTLL 353
                      ||::.::.|..|..:||:||:|. |.:||.|..:|...|||.||.||||||||||
Human   119 VYNMSHEDPGNVSYSEIGGLSEQIRELREVIELPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLL 183

  Fly   354 ARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKR--TNSV 416
            |||||.:....|.........:..:|:.||.:|::|..|:...||:||:||||::|.:|  ..:.
Human   184 ARAVASQLDCNFLKVVSSSIVDKYIGESARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTS 248

  Fly   417 LHPYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEIL 481
            ......:|:.:||::||||.....|.::.||||.|.||.|||||||.|.::.:..|:...|.:||
Human   249 ADREIQRTLMELLNQMDGFDTLHRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDIL 313

  Fly   482 SLY---LTKILHDEIDLDMLARGTSGFTGADLENMINQA---ALRAAID 524
            .::   :||  |.|||.:.:.:.:.||.||||.|:..:|   |:||..|
Human   314 KIHAGPITK--HGEIDYEAIVKLSDGFNGADLRNVCTEAGMFAIRADHD 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	HflB	258..737	CDD:440233	110/316 (35%)
PSMC6	NP_002797.4	PRK03992	5..379	CDD:179699	125/374 (33%)