DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment YME1L and afg3l1

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_005163264.1	Gene:	afg3l1 / 570430	ZFINID:	ZDB-GENE-121214-51	Length:	751	Species:	Danio rerio

Alignment Length:	451	Identity:	198/451 - (43%)
Similarity:	281/451 - (62%)	Gaps:	18/451 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 EEINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEA 361
            :.|.|.|:||.||:|||.|:.|.|.|||:|:::.:||.|:|||.:|.|||||||||||:|.||||
Zfish   253 DSIEVKFKDVAGCEEAKVEIMEFVNFLKNPQQYQDLGAKIPKGAVLSGPPGTGKTLLAKATAGEA 317

  Fly   362 KVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLHPYANQ--T 424
            .|||....|.||.|:.||.|..||||:|..|:..|||::||||||:||.||........:.|  |
Zfish   318 NVPFITVNGSEFLEMFVGVGPARVRDMFALARKNAPCILFIDEIDAVGKKRGGGNFGGNSEQENT 382

  Fly   425 INQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKI- 488
            :||||.|||||:.:..|:||..|||.|.||.||:||||||.::.:..||..||..|..::|..:
Zfish   383 LNQLLVEMDGFNSSTNVVVLAGTNRPDVLDPALMRPGRFDRQIYLGPPDIKGRASIFKVHLRPLK 447

  Fly   489 LHDEIDLDMLAR----GTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKA 549
            |...:|.|.:||    .|.||||||:.|:.|:|||.||....|:||:||.|.|.|:|:.|.|:|.
Zfish   448 LDPSVDRDAIARKMAAATPGFTGADIANVCNEAALIAARYLNESVSVKHFEQAIDRVIGGLEKKT 512

  Fly   550 RLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQLLAM 614
            ::.........||||.|||:|.::.:.:.||.||:|:|||..||:..|:| ||:|..|:.||...
Zfish   513 QVLQPTEKKTVAYHEAGHAVVGWFLQHADPLLKVSIIPRGKGLGYAQYLP-KEQYLYTREQLFDR 576

  Fly   615 MDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGLGTGDTL 679
            |..|:|||.||::.|  :|||:||..|||:.|..|...:..:|||::||..:.:..:   .|:|:
Zfish   577 MCMMLGGRVAEQVFF--NKITTGAHDDLKKVTQSAYAQIVQFGMSERVGQVSFDLPR---QGETV 636

  Fly   680 -----GPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAIL 735
                 ...|.|.:|.|::.::..:|.|...::.:...:...:.:.||:.|.||..|:..:|
Zfish   637 LEKPYSEATAELIDEEVRDLVDRAYRRTLELVTEKREQVDMVGKRLLEKEVLDKADMLELL 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	198/451 (44%)
afg3l1	XP_005163264.1	FtsH_ext	100..191	CDD:284011
		FtsH_fam	206..698	CDD:273520	198/451 (44%)
		AAA	298..428	CDD:278434	74/129 (57%)
		Peptidase_M41	514..696	CDD:279742	63/187 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920