Protein Alignment YME1L and PSMC3

DIOPT Version :10

• Sequence 1: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_002795.2
• Gene: PSMC3 / 5702
• HGNCID: 9549
• Length: 439
• Species: Homo sapiens
• Alignment Length: 451
• Identity: 137/451 - (30%)
• Similarity: 215/451 - (47%)
• Gaps: 65/451 - (14%)

  Fly   148 ITPGLLRPLFSQQQLNQIRGFKTDRSIEAEQKRNPTMTSRLKNALANSPQR---LDGDTPLQAEK 209
            :.|.:..|:..|:::..:..       ||||  :......||.:.....||   ||.:..:...:
Human     3 LLPNIESPVTRQEKMATVWD-------EAEQ--DGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSE 58

  Fly   210 LRRL---LAKSEEHGFNKAESLKIAFAEGYLAA-----------------ANSE-DSPKSGK-TM 252
            :.|:   |...::.....:|.:|:.....||.:                 ||.: ||.:.|| .:
Human    59 VLRVTHELQAMKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAV 123

  Fly   253 KYLKTLQTIVVIVV------------FLGI------FLSFFTTSNGSVFRSIQLGNQVEVDPEEI 299
            ....|.||..:.|:            .:|:      .|....|...|..::      :||| |..
Human   124 IKTSTRQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKA------MEVD-ERP 181

  Fly   300 NVTFEDVKGCDEAKQELKEVVEF-LKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKV 363
            ...:.|:.|.|:..|||.|.:.. :...|||.|||.:.|||||:.|||||||||||||.|.:.|.
Human   182 TEQYSDIGGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKA 246

  Fly   364 PFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNS--VLHPYANQTIN 426
            .|...|||:..::.:|.||:.|||.|..||.:||.:|||||:|::|.||.:|  .......:|:.
Human   247 TFLKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQRTML 311

  Fly   427 QLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKI-LH 490
            :||:::|||..|..|.|:.||||.|.||.||||.||.|.::....|:...|..|:.::..|: :.
Human   312 ELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQIHSRKMNVS 376

  Fly   491 DEIDLDMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKARL 551
            .:::.:.|||.|..|.||..:.:..:|.:.|...||  ..:.|.:.....:.:..::||.|
Human   377 PDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGA--TELTHEDYMEGILEVQAKKKANL 435

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	HflB	258..737	CDD:440233	111/316 (35%)
PSMC3	NP_002795.2	PRK03992	39..432	CDD:179699	125/401 (31%)