Protein Alignment YME1L and PSMC1

DIOPT Version :10

• Sequence 1: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_002793.2
• Gene: PSMC1 / 5700
• HGNCID: 9547
• Length: 440
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 132/427 - (30%)
• Similarity: 209/427 - (48%)
• Gaps: 64/427 - (14%)

  Fly   167 GFKTDRSIEAEQKRNPTMTSRL-----KNALANSPQRLDGDTP--------LQAEKLRRLLAKSE 218
            |.|.|:  :.::|..|.:.:|:     |....::..:|...||        |:.|:::..|...|
Human    14 GKKDDK--DKKKKYEPPVPTRVGKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEE 76

  Fly   219 EHGFNKAESLKIAFAEGYLAAANSEDSPK----SGKTMKYLKTLQTIV-----VIVVFLG----- 269
            |...|: |.:|      .|.....|:..|    .|..|. :.||:.|:     ::...:|
Human    77 EFIRNQ-EQMK------PLEEKQEEERSKVDDLRGTPMS-VGTLEEIIDDNHAIVSTSVGSEHYV 133

  Fly   270 IFLSFFTTSNGSVFRSIQLGN--------------------QVEVDPEEINVTFEDVKGCDEAKQ 314
            ..|||..........|:.|.:                    :||..|:|   |:.|:.|.|...|
Human   134 SILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQE---TYADIGGLDNQIQ 195

  Fly   315 ELKEVVEF-LKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLV 378
            |:||.||. |..||.:..:|.|.||||:|.|||||||||||:|||.:....|....|.|..:..:
Human   196 EIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYL 260

  Fly   379 GQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKR--TNSVLHPYANQTINQLLSEMDGFHQNAGV 441
            |.|.:.||:||:.|:..||.::||||||::|.||  :||.......:|:.:||:::|||.....|
Human   261 GDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDV 325

  Fly   442 IVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKI-LHDEIDLDMLARGTSGF 505
            .|:.||||.:.||.||:||||.|.::....||...:|.|..::.::: |.|::.||.|.......
Human   326 KVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDL 390

  Fly   506 TGADLENMINQAALRAAIDGAETVSMKHLETARDKVL 542
            :|||::.:..:|.|.|..:....|:.:..:.:::.||
Human   391 SGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVL 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	HflB	258..737	CDD:440233	108/319 (34%)
PSMC1	NP_002793.2	PTZ00361	1..440	CDD:185575	132/427 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..49		7/36 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	84..104		4/25 (16%)