Protein Alignment YME1L and afg3l2

DIOPT Version :9

• Sequence 1: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001104667.1
• Gene: afg3l2 / 569168
• ZFINID: ZDB-GENE-070912-46
• Length: 800
• Species: Danio rerio
• Alignment Length: 821
• Identity: 263/821 - (32%)
• Similarity: 385/821 - (46%)
• Gaps: 186/821 - (22%)

  Fly    22 HYYSVNRTKLHGSAGAARLSKSTSTSSRSHDLVLDLRNLLSRSSASIQGMVERAARLNGILDRR- 85
            |.|      ||.|.|...|         .|.|:.::|:  :....|:||:.:.      :||||
Zfish     3 HRY------LHLSRGCRNL---------LHTLLPNVRS--TNRFQSVQGVGQI------VLDRRS 44

  Fly    86 LVDDVLA---KVTSMLPSMRDVRVTLEESATQIGRVQLQNYQFEVSLTGAAGSVPTGANVKVIPT 147
            |:..||.   :::|..|.                  ..:.|.......|...|.||.:|.:|...
Zfish    45 LLSQVLGTYRRLSSKPPK------------------GFEKYFPNNKNGGPKNSEPTPSNAEVKEA 91

  Fly   148 ITPGLLRPLFSQQQLNQIRGFKTDRSIEAEQKRNPTMTSRLKNA--------------------- 191
                  :|..||:......|..:.......:|...|..||::..
Zfish    92 ------KPTNSQKTTGGGGGGSSGGGKRGGRKDESTWQSRIQKGEFPWDDKEFRMYFLGGTAFWL 150

  Fly   192 -------------------LANS------PQRLD-------------GDTPLQAEKL-------- 210
                               ..||      ..||:             |.||:..:.:
Zfish   151 AMGYYFFIRDGGREVTWKDFVNSYLAKGVVDRLEVVNKRYVKVIFTPGKTPVDGQYVWFNIGSVD 215

  Fly   211 ---RRLLAKSEEHGFNKAESLKIAFAEGYLAAANSEDSPKSGKTMKYLKTLQTIVVIVVFL---- 268
               |.|.....|.|......|.:.:      :|.|:.|        :|.::...|:|:.||
Zfish   216 TFERNLETAQLELGIEGENRLPVVY------SAESDGS--------FLLSMLPTVLIIGFLLFML 266

  Fly   269 ---------------GIFLSFFTTSNGSVFRSIQLGNQVEVDPEEINVTFEDVKGCDEAKQELKE 318
                           |:|....||:  .|.|            :||:|.|:||.||:|||.|:.|
Zfish   267 RRGPAGAGRPGRGMGGLFSVSETTA--KVLR------------DEIDVKFKDVAGCEEAKLEIME 317

  Fly   319 VVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGAR 383
            .|.|||:|:::.:||.|:|||.:|.|||||||||||:|.||||.|||....|.||.|:.||.|..
Zfish   318 FVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEANVPFITVNGSEFLEMFVGVGPA 382

  Fly   384 RVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLHPYANQ--TINQLLSEMDGFHQNAGVIVLGA 446
            ||||||..|:..|||::||||||:||.||........:.|  |:||||.|||||:....|:||..
Zfish   383 RVRDLFVLARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTLNQLLVEMDGFNTATNVVVLAG 447

  Fly   447 TNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKI-LHDEIDLDMLARG----TSGFT 506
            |||.|.||.||:||||||.::.:..||..||..|..::|..: |..|:|.:.|||.    |.||:
Zfish   448 TNRPDILDPALMRPGRFDRQIYIGPPDIKGRASIFKVHLRPLKLEAELDKEALARKMAALTPGFS 512

  Fly   507 GADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVA 571
            |||:.|:.|:|||.||...::.::.||.|.|.::|:.|.|:|.::...|.....||||.|||:..
Zfish   513 GADIANVCNEAALIAARHLSDAINQKHFEQAIERVIGGLEKKTQVLQPEEKKTVAYHEAGHAVAG 577

  Fly   572 FYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITS 636
            ::.:.:.||.||:|:|||..||:..|:| ||:|..||.|||..|...:|||.:||:.||  :||:
Zfish   578 WFLEHADPLLKVSIIPRGKGLGYAQYLP-KEQYLYTKEQLLDRMCMTLGGRVSEEIFFG--RITT 639

  Fly   637 GASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGLGTGDTL-----GPNTIEAVDAEIKRILS 696
            ||..|||:.|..|...:..:||::|||..:.:..:   .|:.:     ...|...:|.|::.::|
Zfish   640 GAQDDLKKVTQSAYAQIVQFGMNEKVGQVSFDLPR---QGELVLEKPYSEATARLIDTEVRNLIS 701

  Fly   697 DSYERAKAILRKHTREHKALAEALLKYETLDADDIKAILNE 737
            .:|||.:.:|.....|.:.:|..||:.|.||.:|:..:|.:
Zfish   702 TAYERTQQLLSDKKPEVEKVALRLLEKEVLDKNDMVELLGK 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	210/512 (41%)
afg3l2	NP_001104667.1	FtsH_ext	141..237	CDD:284011	11/95 (12%)
		FtsH_fam	248..741	CDD:273520	210/512 (41%)
		AAA	340..471	CDD:278434	75/130 (58%)
		Peptidase_M41	557..739	CDD:279742	67/187 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.020