DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and yme1l1b

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_001317997.1	Gene:	yme1l1b / 557907	ZFINID:	ZDB-GENE-070410-25	Length:	715	Species:	Danio rerio

Alignment Length:	796	Identity:	343/796 - (43%)
Similarity:	468/796 - (58%)	Gaps:	150/796 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFSTTTHSVPYLYLGNFSRKPHYYSVNRTKLHGSAGAARLSKSTSTSSRSHDLVLDLRNLLSRSS 65
            |||.:|...|.:.:    :..|..:.    ||...|:...:.|.|...|.:....||.:  :..|
Zfish     1 MFSLSTTLQPQVTV----QLSHLINA----LHSLKGSVSSNTSVSHKHRENTPEQDLNS--TEPS 55

  Fly    66 ASIQGMVERAARLNGILDRRLV--DDVLAKVTSMLPSMRDVRVTLEESATQIGRVQLQNYQFEVS 128
            .|::.:        |:.|..||  |::|.|   :||     ||:.::|
Zfish    56 LSLRDL--------GLSDLGLVQIDELLEK---LLP-----RVSQQDS----------------- 87

  Fly   129 LTGAAGSVPTGANVKVIPTI-------------------TPGLLRPLFSQQQ------------- 161
                        .:|.:|.|                   ..|.:.|:||:|.
Zfish    88 ------------QLKTVPDIWRTSHLSSDSFFHNKHGFSRMGGVTPVFSRQNQSPLQTLCTDLNY 140

  Fly   162 ---LNQIRGFKTDRSIEAEQKRNPTMTSRLKNALANSPQRLDGDTPL------------QAEKLR 211
               |.|.|||||.:|          .|.||:... ..|...:|.||.            ..|.|.
Zfish   141 LPLLVQNRGFKTLKS----------RTRRLQGGF-EGPVEPEGITPSFMKGFLTRDKGPDVETLE 194

  Fly   212 RLLAKSEEHGFNKAESLKIAFAEGYLAAANSEDSPKSGKTMKYLKTLQTIVVIVVFLGI------ 270
            :|| |::.....:.::.|..||||:|.|     ...:.:|.:.|:..:.|:::::.:|:
Zfish   195 KLL-KNKNIPEGQHDAFKTGFAEGFLKA-----QALTQRTQESLRRTRLILLVLLLVGLYGLSKT 253

  Fly   271 -FLS--FFTTSNGSVFRSIQLGNQVEVDPEEI-NVTFEDVKGCDEAKQELKEVVEFLKSPEKFSN 331
             |||  |.|||          |....|||.:: |||||.|||.:|||.||:||||||::|:||:.
Zfish   254 PFLSVRFRTTS----------GLDSAVDPVQMKNVTFEHVKGVEEAKNELQEVVEFLRNPQKFTV 308

  Fly   332 LGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARA 396
            ||||||||:|||||||||||||||||||||.|||::|:|.||||:.||.||.|:|:||:.||..|
Zfish   309 LGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKGNA 373

  Fly   397 PCVIFIDEIDSVGAKRTNSVLHPYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPG 461
            ||||||||:||||.||..|.:|||:.|||||||:|||||..|.|||::||||..:.||.||:|||
Zfish   374 PCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPG 438

  Fly   462 RFDVEVMVSTPDFTGRKEILSLYLTKILHDE-IDLDMLARGTSGFTGADLENMINQAALRAAIDG 525
            |||::|.|..||..||.|||..||.||..|. ::.:::||||.||:||:|||::|||||:||:||
Zfish   439 RFDMQVTVPRPDVKGRTEILKWYLKKIKVDSAVEAEVIARGTVGFSGAELENLVNQAALKAAVDG 503

  Fly   526 AETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGP 590
            .:.|:||.||.|:||:||||||::...|:....||||||.||||:|:|||::.|::|.|||||||
Zfish   504 KDMVTMKELEFAKDKILMGPERRSAEIDKRNKEITAYHESGHAIIAYYTKDAMPINKATIMPRGP 568

  Fly   591 SLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRD 655
            :|||.:.:||.:|:..|:|||||.||..||||.||||:||.:.||:|||||...||.||..||..
Zfish   569 TLGHVSMLPENDRWSETRAQLLAQMDVSMGGRVAEELIFGNENITTGASSDFDSATKIAKMMVTR 633

  Fly   656 WGMSDKVGLRTI-EASKGLGTGDTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEA 719
            :|||:|:|:.|. :.:|       ..|.|..|::.|::.:|.||||||||:|:...:||:.||||
Zfish   634 FGMSEKLGVMTYSDLTK-------QSPETQAAIEHEVRILLRDSYERAKALLKSRAKEHRNLAEA 691

  Fly   720 LLKYETLDADDIKAIL 735
            ||:||||||.:|:.:|
Zfish   692 LLRYETLDAKEIQLVL 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	279/494 (56%)
yme1l1b	NP_001317997.1	FtsH_fam	275..708	CDD:273520	265/440 (60%)
		AAA	317..448	CDD:278434	91/130 (70%)
		Peptidase_M41	528..704	CDD:279742	96/182 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170578448
Domainoid	1	1.000	198	1.000	Domainoid score	I3035
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31996
Inparanoid	1	1.050	550	1.000	Inparanoid score	I1104
OMA	1	1.010	-	-		QHG53805
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	1	1.000	-	-		FOG0003122
OrthoInspector	1	1.000	-	-		otm26273
orthoMCL	1	0.900	-	-		OOG6_101196
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.810