DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and CG6512

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_730248.2	Gene:	CG6512 / 39922	FlyBaseID:	FBgn0036702	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	780	Identity:	257/780 - (32%)
Similarity:	375/780 - (48%)	Gaps:	174/780 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 LEESATQIGRVQLQNYQFEVSLTGAAGSVP----------TGANVKVIPTITPGLLRPLFSQQQL 162
            |..:.|..|.:: :||        .|||:|          |||.|.::||....|||.:..|.||
  Fly     6 LGTAKTMAGMMR-RNY--------TAGSLPGKGQRTHMGATGAGVYILPTELSPLLRYVVKQIQL 61

  Fly   163 --------------------NQIRGFKTDR------SIEAEQKRNPTMTSRLKNALANSPQRLD- 200
                                .|.:|...|:      |..|.:|.:.:..:.:|.:.:.:..:.|
  Fly    62 LCKKPPKGFEKYFEAGGKSSGQPKGSVGDKKPPAGSSKSASEKPSTSTPASVKPSRSQTDAKSDW 126

  Fly   201 --------------------GDTPL---------------------------------------- 205
                                |..||
  Fly   127 NFGMFSNSSRGPAGKGGNSLGGRPLGENGGGGDRERWILLGAIGAVVLVGSFAFFEMGYKEISWK 191

  Fly   206 ----------QAEKL--------RRLLAKSEEHG-----FN--KAESLKIAFAEGYLAAANSEDS 245
                      ..|||        |..|.::...|     ||  ..:|.     |..|.||.:|..
  Fly   192 EFVNSYLSKGVVEKLEVVNKKWVRVRLQQNSNSGSGVLWFNIGSVDSF-----ERNLEAAQTEQG 251

  Fly   246 PKSGKTMKYL-------KTLQTIVVIVVFLGIFLSFFTTS-----------NGSVFRSIQLGNQV 292
            .:|...:..:       .:|..::..::.:|..:.....|           .|.:|..:......
  Fly   252 TESINFVPVIYRNEVEAASLTGLLPTLLIIGFLVYMMRKSADMMGGGRGRKGGGLFGGVMQSTAK 316

  Fly   293 EVDPEEINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAV 357
            ..:|.||.|.|:||.||:|||.|:.|.|.|||:|:::.:||.|:|||.:|.|||||||||||:|.
  Fly   317 LTNPNEIGVGFKDVAGCEEAKIEIMEFVNFLKNPQQYIDLGAKIPKGAMLTGPPGTGKTLLAKAT 381

  Fly   358 AGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVL--HPY 420
            ||||.|||...:|.||.|:.||.|..||||:|..|:..|||::||||||:||.||.....  |..
  Fly   382 AGEANVPFITVSGSEFLEMFVGVGPSRVRDMFAMARKHAPCILFIDEIDAVGRKRGGKTFGGHSE 446

  Fly   421 ANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYL 485
            ...|:||||.|||||:....|:||.||||.|.||:||:||||||.::.|..||..||..|..::|
  Fly   447 QENTLNQLLVEMDGFNTTTNVVVLAATNRVDILDKALMRPGRFDRQIYVPAPDIKGRASIFKVHL 511

  Fly   486 ----TKILHDEIDLDMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPE 546
                |.:..:|:...|.|. |.||||||:.|:.|:|||.||.|..:::.:||.|.|.::|:.|.|
  Fly   512 GNLKTSLDKNELSRKMAAL-TPGFTGADIANVCNEAALIAARDSKDSIVLKHFEQAIERVIAGME 575

  Fly   547 RKAR-LPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQ 610
            :|.. |..||..|: |:||.|||:..::.:.:.||.||:|:|||..||:..|:| |:.|.::|.|
  Fly   576 KKTNVLAPEEKRTV-AHHEAGHAVAGWFLEHADPLLKVSIIPRGKGLGYAQYLP-KDHYLLSKEQ 638

  Fly   611 LLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGLGT 675
            |...|...:|||.||||.|  ::||:||..|||:.|.||...|..:||::|||..:.:..:   .
  Fly   639 LFDRMCMTLGGRVAEELFF--NRITTGAQDDLKKITDIAYSQVVRFGMNEKVGQVSFDVGQ---A 698

  Fly   676 GDTL-----GPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAIL 735
            ||.:     ..:|.:.:|.|::.|:..::|...::|.||....:.:||.||:.|.|..||:..:|
  Fly   699 GDPVFSKPYSEDTAQLIDNEVRSIIKCAHEATTSLLTKHKENVQKVAERLLQNEVLSRDDMIELL 763

Fly 736 735
Fly 764 763

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	210/512 (41%)
CG6512	NP_730248.2	FtsH_ext	163..259	CDD:284011	15/100 (15%)
		FtsH_fam	271..764	CDD:273520	210/501 (42%)
		AAA	365..496	CDD:278434	75/130 (58%)
		Peptidase_M41	580..762	CDD:279742	70/188 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438377
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850