DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and Spg7

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_008770841.1	Gene:	Spg7 / 353231	RGDID:	727940	Length:	781	Species:	Rattus norvegicus

Alignment Length:	804	Identity:	254/804 - (31%)
Similarity:	388/804 - (48%)	Gaps:	165/804 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PYLYLGNFSRKPHYYSVNRTKLHGSAGAARLSKSTSTSSRSHDLVLDLRNLLSRSSASIQGM--- 71
            |.|:.|...|:|  |.|..|.:..:|......:|.            |..:|:.|...:.|:
  Rat    31 PGLFSGAGGRRP--YVVRGTPIGLAAAGGHTPQSL------------LLRILTPSFEGVSGLLLK 81

  Fly    72 ---VERAARL------------NGILDRRLVDD-------------------------------- 89
               |..|.||            :|:..:...||
  Rat    82 RHIVPSAIRLWQLSGSTLYFNTSGLKQKNKDDDKPKGKAPEDDEEERRRKEREDQMYRERLRTLF 146

  Fly    90 VLAKVTSMLPSMRDVRVTLEESATQIGRVQLQNYQFEVSLTGAAGSVPTGANVKVIPT------- 147
            ::|.|.|:|.|:          :|..|.:...::..|:.   |.|.|   ..|:|:|.
  Rat   147 IIAIVMSLLNSL----------STSGGSISWADFVNEML---AKGEV---QRVQVVPESDVVEVY 195

  Fly   148 ITPGLL---RP---LFSQQQLNQIRGFKTDRSIEAEQKRNPTMTSRLKNALANSPQRLDGDTPLQ 206
            :.||.:   ||   |..:.|:..|..|:
  Rat   196 LHPGAVVFGRPRLALMYRMQVANIDKFE------------------------------------- 223

  Fly   207 AEKLRRLLAKSEEHGFNKAESLKIAFAE-GYLAAANSEDSPKSGKTMKYLKTLQTIVVIVVFLGI 270
             ||||   |..:|......:.:.:::.. |:...|            .|...:..:.:.:::...
  Rat   224 -EKLR---AAEDELNIESKDRIPVSYKRTGFFGNA------------LYALGMTAVGLAILWYVF 272

  Fly   271 FLSFFTTSNG--SVFRSIQLGNQVEVDPEE-INVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNL 332
            .|:..|...|  |.|..:::.....||.:. ..|:|:||.|..|||.|::|.|::|||||:|..|
  Rat   273 RLAGMTGREGGFSAFNQLKMARFTIVDGKTGKGVSFQDVAGMHEAKLEVREFVDYLKSPERFLQL 337

  Fly   333 GGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAP 397
            |.|:|||.||:||||.||||||:|||.||:|||...|||||.||:.|.||.|||.|||.|:||||
  Rat   338 GAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAP 402

  Fly   398 CVIFIDEIDSVGAKRTNSVLHPYAN----QTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALL 458
            |:::|||||:||.||:.| :..::|    ||:||||.||||......||||.:|||.|.||.||:
  Rat   403 CIVYIDEIDAVGKKRSTS-MSGFSNTEEEQTLNQLLVEMDGMGTADHVIVLASTNRADVLDNALM 466

  Fly   459 RPGRFDVEVMVSTPDFTGRKEILSLYL--TKILH-DEIDLDMLARGTSGFTGADLENMINQAALR 520
            ||||.|..|.:..|....|:||...:|  .|:.. .......||..|.||:|||:.|:.|:|||.
  Rat   467 RPGRLDRHVFIDLPTLQERREIFEQHLKGLKLTQPSSFYSQRLAELTPGFSGADIANICNEAALH 531

  Fly   521 AAIDGAETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTI 585
            ||.:|..:|...:.|.|.::|:.|..:|:::..:|...:.|:||.|||:|.:..:.:..:.||:|
  Rat   532 AAREGHTSVHTFNFEYAVERVIAGTAKKSKILSKEEQRVVAFHESGHALVGWLLEHTEAVMKVSI 596

  Fly   586 MPR-GPSLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIA 649
            .|| ..:||.:..:| :::|..||.||...|...:||||||.:.|  .::||||..||::.|.||
  Rat   597 APRTNAALGFSQMLP-RDQYLFTKEQLFERMCMALGGRAAEAISF--SRVTSGAQDDLRKVTRIA 658

  Fly   650 THMVRDWGMSDKVG-LRTIEASKGL-GTG-DTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTR 711
            ..||:.:||:..:| :...||.:|| |.| ........:.:|.|.:.:::.:|...:.:|..:..
  Rat   659 YSMVKQFGMAPSIGPVSFPEAQEGLVGIGRRPFSQGLQQMMDHEARLLVARAYRHTEKVLLDNLD 723

  Fly   712 EHKALAEALLKYETLDADDIKAIL 735
            :.:|||.|||:.|.::.:||:|::
  Rat   724 KLQALANALLEKEVINYEDIEALI 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	203/496 (41%)
Spg7	XP_008770841.1	FtsH_ext	145..242	CDD:310823	28/153 (18%)
Spg7	XP_008770841.1	TIP49	265..748	CDD:332389	202/487 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820