Protein Alignment YME1L and Afg3l2

DIOPT Version :9

• Sequence 1: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001128336.1
• Gene: Afg3l2 / 307350
• RGDID: 1305259
• Length: 802
• Species: Rattus norvegicus
• Alignment Length: 580
• Identity: 220/580 - (37%)
• Similarity: 323/580 - (55%)
• Gaps: 82/580 - (14%)

  Fly   201 GDTPLQAEKL-----------RRLLAKSEE---HGFNKAESLKIAFAEGYLAAANSEDSPKSGKT 251
            |.||:..:.:           |.|....:|   .|.|:...:.||.::|
  Rat   202 GKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDG---------------- 250

  Fly   252 MKYLKTLQTIVVIVVFL-------------------GIFLSFFTTSNGSVFRSIQLGNQVEVDPE 297
             .:|.::...|:|:.||                   |:|....||:              :|..:
  Rat   251 -SFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTA--------------KVLKD 300

  Fly   298 EINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAK 362
            ||:|.|:||.||:|||.|:.|.|.|||:|:::.:||.|:|||.:|.|||||||||||:|.||||.
  Rat   301 EIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEAN 365

  Fly   363 VPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLHPYANQ--TI 425
            |||...:|.||.|:.||.|..||||||..|:..|||::||||||:||.||........:.|  |:
  Rat   366 VPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTL 430

  Fly   426 NQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKI-L 489
            ||||.|||||:....|::|..|||.|.||.|||||||||.::.:..||..||..|..::|..: |
  Rat   431 NQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKL 495

  Fly   490 HDEIDLDMLARG----TSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKAR 550
            ...::.|.|||.    |.||:|||:.|:.|:|||.||...::.::.||.|.|.::|:.|.|:|.:
  Rat   496 DSALEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDAINEKHFEQAIERVIGGLEKKTQ 560

  Fly   551 LPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQLLAMM 615
            :...|.....||||.|||:..:|.:.:.||.||:|:|||..||:..|:| ||:|..||.|||..|
  Rat   561 VLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLP-KEQYLYTKEQLLDRM 624

  Fly   616 DTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGLGTGDTL- 679
            ...:|||.:||:.||  :||:||..||::.|..|...:..:||::|||..:.:..:   .||.:
  Rat   625 CMTLGGRVSEEIFFG--RITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPR---QGDMVL 684

  Fly   680 ----GPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAIL 735
                ...|...:|.|::.::|::|:|..|:|.:...:.:.:|..||:.|.||.:|:..:|
  Rat   685 EKPYSEATARMIDDEVRILISEAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELL 744

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	209/513 (41%)
Afg3l2	NP_001128336.1	FtsH_ext	145..241	CDD:284011	8/38 (21%)
		FtsH_fam	252..745	CDD:273520	209/513 (41%)
		AAA	344..475	CDD:278434	75/130 (58%)
		Peptidase_M41	561..743	CDD:279742	67/187 (36%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920