DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and yta12

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_596797.1	Gene:	yta12 / 2541079	PomBaseID:	SPBC543.09	Length:	773	Species:	Schizosaccharomyces pombe

Alignment Length:	777	Identity:	261/777 - (33%)
Similarity:	406/777 - (52%)	Gaps:	99/777 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PYLYLGNFSRKPHYYSVNRTKLHGSAGAARLSKSTSTSSRSHDLVLDLRNLLSRSSASIQGMVER 74
            |:|.....:||...|.|::.....:..:.||:::.:.|:||  ..:...:|||.|..|.|.:
pombe     4 PFLTFRAPTRKTGDYLVSKFVKKDNFSSLRLARAYTFSTRS--TAVSQFSLLSLSQRSFQSL--- 63

  Fly    75 AARLN-GILDRRLVDDVLAKVTSMLPSMRDVRVTLEESATQIGRVQLQNYQ-------------- 124
              ::| ||.::..:..:.:|..| :.|.|....:...::...||...|...
pombe    64 --KINKGIPEKHKIPLISSKQFS-VTSKRSQNGSSGSNSDANGRKNGQKNDDSKKKGLNGNDPKK 125

  Fly   125 -FEVSLTG--AAGSVPTGANVKVIPTITPGLLRPLFSQQQLNQIRGFKTDRSIEAEQKRNPTMTS 186
             ||::|.|  ..|.:       ::..|...:|.|..:.|::.. :.|:       :|..:..:..
pombe   126 VFEIALNGNTILGGI-------LVAYILYNVLSPNANMQEITW-QDFR-------QQFLDKGLVE 175

  Fly   187 RLKNALANSPQRLDGDTPLQAEKLRRLLAKSEEHGFNKAESL-----KIAFAEGYLAAANSEDSP 246
            ||.....|..:.:          ||..:|......:....|:     |:..|:..|....||..|
pombe   176 RLVVVNRNMVRVI----------LRGGVASGSGQYYFSIGSIDSFDRKLEDAQRQLGIPPSEFVP 230

  Fly   247 KS-GKTMKYLKTLQTIVVIVVFLG--IFLSFFTT-----SNGSVF-----RSIQLGNQVEVDPEE 298
            .: ...:..|.||.:....::.:|  |:||...:     ..|.:|     |:....::.     :
pombe   231 VAYHDEVSVLATLLSFAPTLLIIGSVIYLSRRASGAAGGGQGGIFGIGKSRAKMFNHET-----D 290

  Fly   299 INVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKV 363
            |.:.|.||.|.||||:|:.|.|:|||:|:.:..||.|:|:|.:|.|||||||||||:|.||||.|
pombe   291 IKIKFADVAGVDEAKEEIMEFVKFLKNPKFYERLGAKIPRGAILSGPPGTGKTLLAKATAGEANV 355

  Fly   364 PFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKR-------TNSVLHPYA 421
            ||...:|.||.|:.||.|..||||||..|:..|||:|||||||::|..|       :|.    ..
pombe   356 PFLSVSGSEFLEMFVGVGPSRVRDLFATARKNAPCIIFIDEIDAIGKARGRGGQFGSND----ER 416

  Fly   422 NQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLT 486
            ..|:||||.|||||..:..::|...|||.|.||.|||||||||.::.:..||..||::|..::|.
pombe   417 ESTLNQLLVEMDGFTSSEHIVVFAGTNRPDVLDPALLRPGRFDRQITIDRPDIGGREQIFKVHLK 481

  Fly   487 KI-LHDEIDL--DMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERK 548
            .| ..|.|||  ..||..||||||||:.|:.|:.||.||...:..|.|.|.|.|.::|..|.|:|
pombe   482 HIKAADNIDLIAKRLAVLTSGFTGADIMNVCNEGALIAARSNSNEVQMVHFEQAIERVTAGLEKK 546

  Fly   549 AR-LPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQLL 612
            :| |..||.||: |:||.|||:..::.:...||.||:|:||..:||:.:|:| |::|.:::.|:|
pombe   547 SRVLSPEEKNTV-AHHEAGHAVAGWFMEYVDPLLKVSIIPRAQALGYASYLP-KDQYLMSRGQIL 609

  Fly   613 AMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGLGTGD 677
            ..|...:.||.:||:.||.:|||||||.|.::.|.:|...|..:|||..||  ||  :..:.|.:
pombe   610 DQMGMALAGRVSEEIFFGPEKITSGASDDFQKVTRMAQAYVTQYGMSPTVG--TI--AYPIDTRE 670

  Fly   678 TL----GPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAIL 735
            |:    ...|.:.:|.||::::..:|||.|.:|.:|.:..:.:|:.||:.|.:..::::.||
pombe   671 TVQKPFSEATAQMIDEEIRKLVKHAYERTKKLLLEHKQGLENIAQRLLQKEVITYNEVETIL 732

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	210/509 (41%)
yta12	NP_596797.1	FtsH_ext	136..230	CDD:284011	19/118 (16%)
		FtsH_fam	238..733	CDD:273520	210/510 (41%)
		AAA	333..466	CDD:278434	73/136 (54%)
		Peptidase_M41	548..731	CDD:279742	68/188 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910