DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and SPCC965.04c

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_588514.1	Gene:	SPCC965.04c / 2538746	PomBaseID:	SPCC965.04c	Length:	709	Species:	Schizosaccharomyces pombe

Alignment Length:	500	Identity:	242/500 - (48%)
Similarity:	339/500 - (67%)	Gaps:	17/500 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 DSPKSGKTMKYLKTLQTIVVIVVFLGIFLSFFTTSNGSVFRSIQLGNQVEVDPEE---INVTFED 305
            |.|:..|..:..|.:..:.|...|:.:.:|.|..::|  ..:| :.|..|.:|.|   |||.|.|
pombe   207 DEPRFTKFFRIFKFIAGLSVASYFVLLGMSIFAETSG--LNNI-MTNTTEQEPMEERAINVRFSD 268

  Fly   306 VKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAG 370
            |:|.||||:||:|:|:||:.|..|:.||||||:||||.||||||||:|||||||||.||||..:|
pombe   269 VQGVDEAKEELEEIVDFLRDPTHFTRLGGKLPRGVLLTGPPGTGKTMLARAVAGEANVPFFFMSG 333

  Fly   371 PEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLHPYANQTINQLLSEMDGF 435
            .:|||:.||.||:|||:||.||:.:||.:|||||:|::|.|| |:....:..||:||||.::|||
pombe   334 SQFDEMYVGVGAKRVRELFAAARKQAPSIIFIDELDAIGQKR-NARDAAHMRQTLNQLLVDLDGF 397

  Fly   436 HQNAG----VIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKI-LHDEIDL 495
            .:|..    |:.:||||..:.||.||.||||||..:.|..||..||..||..:...: |..::||
pombe   398 SKNEDLAHPVVFIGATNFPESLDPALTRPGRFDRHIHVPLPDVRGRLAILLQHTRHVPLGKDVDL 462

  Fly   496 DMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKARLPDEEANTIT 560
            .::|||||||.||||.|:|||||:.|:.:.:..|||:.||.::|::|||.|||:.....|...:|
pombe   463 SIIARGTSGFAGADLANLINQAAVYASKNLSTAVSMRDLEWSKDRILMGAERKSAFITPENKLMT 527

  Fly   561 AYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAE 625
            ||||||||:||.:||.:...:|.||||||.|||.|..:|:.::...|:.:.|||:|..|||||||
pombe   528 AYHEGGHALVALFTKNAMRPYKATIMPRGSSLGMTISLPDMDKDSWTREEYLAMLDVTMGGRAAE 592

  Fly   626 ELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGLGTGDTLGPNTIEAVDAE 690
            ||::|.|||||||.:|:.:||.:|..||.::||||::|..::||..     |.|.|.|...|::|
pombe   593 ELLYGKDKITSGAHNDIDKATQVARRMVTEFGMSDRIGPVSLEAEM-----DNLSPATRALVESE 652

  Fly   691 IKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAIL 735
            ||.:|..||||:.::|:.|.:|..|||.||:.||.|.|:::..::
pombe   653 IKSLLEASYERSLSLLKSHKKELDALATALVDYEFLTAEEMNRVV 697

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	239/489 (49%)
SPCC965.04c	NP_588514.1	FtsH_fam	258..698	CDD:273520	229/445 (51%)
		P-loop_NTPase	266..>322	CDD:304359	39/55 (71%)
		AAA	303..437	CDD:278434	77/134 (57%)
		Peptidase_M41	517..696	CDD:279742	86/183 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	166	1.000	Domainoid score	I930
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	441	1.000	Inparanoid score	I309
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003122
OrthoInspector	1	1.000	-	-		oto101246
orthoMCL	1	0.900	-	-		OOG6_101196
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1955
SonicParanoid	1	1.000	-	-		X2093
TreeFam	1	0.960	-	-
	11	10.750