DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and Spg7

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_694816.3	Gene:	Spg7 / 234847	MGIID:	2385906	Length:	781	Species:	Mus musculus

Alignment Length:	709	Identity:	243/709 - (34%)
Similarity:	362/709 - (51%)	Gaps:	111/709 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 VSLTGAAGSVPTGANVKVI-PT------------ITPGLLR--PL------FSQQQLNQ------ 164
            |....|.|..|....:::: |:            |.|..:|  ||      |:..::.|
Mouse    50 VGPAAAGGHAPQSLLLRILTPSFEGISGLLLKQHIVPNAVRLWPLSGSTLYFNTSRMKQKNKDND 114

  Fly   165 -IRGFKTDRSIEAEQKRNP----------------TMTSRLKNALANSPQRLDGDTPLQAEKLRR 212
             .:| ||....|.|::|..                .:...|.|:|:.|     |.:...|:.:..
Mouse   115 KPKG-KTPEDDEEEKRRKEREDQMYRERLRTLFIIALVMSLLNSLSTS-----GGSISWADFVNE 173

  Fly   213 LLAKSEEH------------------------------------GFNKAESLKIAFAEGYLAAAN 241
            :|||.|..                                    ..:|.|. |:..||..|...:
Mouse   174 MLAKGEVQRVQVVPESDVVEVYLHPGAVVFGRPRLALMYRMQVANIDKFEE-KLRAAEDELNIES 237

  Fly   242 SEDSPKSGKTMKYLKTL-----QTIVVIVVFLGIF-LSFFTTSNG--SVFRSIQLGNQVEVDPEE 298
            .:..|.|.|...:....     .|.|.:.:...:| |:..|...|  |.|..:::.....||.:.
Mouse   238 KDRIPVSYKRTGFFGNALYALGMTAVGLAILWYVFRLAGMTGREGGFSAFNQLKMARFTIVDGKT 302

  Fly   299 -INVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAK 362
             ..|:|:||.|..|||.|::|.|::|||||:|..||.|:|||.||:||||.||||||:|||.||:
Mouse   303 GKGVSFQDVAGMHEAKLEVREFVDYLKSPERFLQLGAKVPKGALLLGPPGCGKTLLAKAVATEAQ 367

  Fly   363 VPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLHPYAN----Q 423
            |||...|||||.||:.|.||.|||.|||.|:|||||:::|||||:||.||:.| :..::|    |
Mouse   368 VPFLAMAGPEFVEVIGGLGAARVRSLFKEARARAPCIVYIDEIDAVGKKRSTS-MSGFSNTEEEQ 431

  Fly   424 TINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYL--T 486
            |:||||.||||......||||.:|||.|.||.||:||||.|..|.:..|....|:||...:|  .
Mouse   432 TLNQLLVEMDGMGTTDHVIVLASTNRADVLDNALMRPGRLDRHVFIDLPTLQERREIFEQHLKGL 496

  Fly   487 KILH-DEIDLDMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKAR 550
            |:.. .......||..|.||:|||:.|:.|:|||.||.:|..:|...:.|.|.::|:.|..:|::
Mouse   497 KLTQPSSFYSQRLAELTPGFSGADIANICNEAALHAAREGHTSVHTFNFEYAVERVIAGTAKKSK 561

  Fly   551 LPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPR-GPSLGHTAYIPEKERYHVTKAQLLAM 614
            :..:|...:.|:||.|||:|.:..:.:..:.||:|.|| ..:||.:..:| :::|..||.||...
Mouse   562 ILSKEEQRVVAFHESGHALVGWLLEHTEAVMKVSIAPRTNAALGFSQMLP-RDQYLFTKEQLFER 625

  Fly   615 MDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVG-LRTIEASKGL-GTG- 676
            |...:||||||.:.|  .::||||..||::.|.||..||:.:||:..:| :...||.:|| |.|
Mouse   626 MCMALGGRAAEAISF--SRVTSGAQDDLRKVTRIAYSMVKQFGMAPSIGPVSFPEAQEGLMGIGR 688

  Fly   677 DTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAIL 735
            ........:.:|.|.|.:::.:|...:.:|..:..:.:|||.|||:.|.::.:||:|::
Mouse   689 RPFSQGLQQMMDHEAKLLVAKAYRHTEKVLLDNLDKLQALANALLEKEVINYEDIEALI 747

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	206/502 (41%)
Spg7	NP_694816.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..56		1/5 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..135		7/32 (22%)
		FtsH_ext	145..242	CDD:284011	16/102 (16%)
		FtsH_fam	265..748	CDD:273520	204/487 (42%)
		AAA	346..479	CDD:278434	81/133 (61%)
		Peptidase_M41	561..746	CDD:279742	63/187 (34%)
		Interaction with PPIF. /evidence=ECO:0000250\|UniProtKB:Q9UQ90	701..781		14/47 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820