Protein Alignment YME1L and ymel-1

DIOPT Version :9

• Sequence 1: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_001366715.1
• Gene: ymel-1 / 176460
• WormBaseID: WBGene00010842
• Length: 723
• Species: Caenorhabditis elegans
• Alignment Length: 713
• Identity: 351/713 - (49%)
• Similarity: 454/713 - (63%)
• Gaps: 74/713 - (10%)

  Fly    53 LVLDLRNLLSRSSASIQGMVERAARLNGILDRRLVDDVLAKVT--SMLPSMRDVRVTLEESATQI 115
            |:.:.||.::|....|:......:|:...:.|:...|..:.||  .|...:||  .||.....:.
 Worm    18 LLRNSRNGINRKPLDIEATAASLSRVYHQVWRQFSSDTSSPVTINQMNNILRD--STLSRRIARK 80

  Fly   116 GRVQLQNYQFEVSLTGAAGSVPTGANVKVIPTITPGLLRPLFSQQQLNQIRGFKTDRSIEAEQKR 180
            ..:.| ||.              .|.|::||.          |.....|.|||:|.:
 Worm    81 SEISL-NYD--------------DAVVRIIPA----------SSSFYIQRRGFRTRK-------- 112

  Fly   181 NPTMTSRLKNALANSPQRLDGDTPLQ--AEKLRRLLAKSEEHGFNK-----------AESLKIAF 232
               .|..:.|  |..|.:.:..:||.  :|.|.....|:.|.|..|           .|:.:..:
 Worm   113 ---QTFGVGN--AGKPTQDEVKSPLTYFSELLAGKKQKTSEGGVEKWNQYESDLKKLPENQQRTY 172

  Fly   233 AEGYLAAANSEDSPKSGKTMKYLKTLQTIVVIVVFLGIFLSFFT---------TSNGSVFRSIQL 288
            .:|::....|.....:||..|...||....:.:||. ||..:.|         ...||:|.|
 Worm   173 TDGFVKGLLSNGVSGAGKDGKKSNTLTRFYIFLVFC-IFFGYLTGRIRVRVGDRQIGSLFFS--- 233

  Fly   289 GNQVEVDPEEINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLL 353
             |..||:||::.|||:||:|.||||.|::|:|::||.|||:|.|||:||||||||||||||||||
 Worm   234 -NPQEVNPEDVQVTFDDVRGMDEAKLEVEEIVDYLKDPEKYSRLGGRLPKGVLLVGPPGTGKTLL 297

  Fly   354 ARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLH 418
            |||:||||:|||||.||.||||||||||||||||||..|||||||:||||||||||:||.::.:|
 Worm   298 ARAIAGEAQVPFFHTAGSEFDEVLVGQGARRVRDLFDKAKARAPCIIFIDEIDSVGSKRVSNSIH 362

  Fly   419 PYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSL 483
            |||||||||||||||||.:|.|:||:.||||.||||:||||||||||.|.|..||..||.:|.:.
 Worm   363 PYANQTINQLLSEMDGFTRNEGIIVIAATNRVDDLDKALLRPGRFDVRVTVPKPDLAGRVDIFNF 427

  Fly   484 YLTKILHD-EIDLDMLARGTSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPER 547
            ||:||:|. .||..:||:|::||||||:|||:|||||:||.|.|..|:|.:|:.|||:|||||.|
 Worm   428 YLSKIVHSGGIDPKVLAKGSTGFTGADIENMVNQAALKAATDNAVEVTMAYLDEARDRVLMGPAR 492

  Fly   548 K-ARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQL 611
            . .|:||||||..|||||.||.:|:.|||::.|||||||:|||.||||||.:|||:.|.:||||:
 Worm   493 TGGRIPDEEANRNTAYHEAGHTLVSLYTKDATPLHKVTIIPRGQSLGHTAMLPEKDSYQLTKAQM 557

  Fly   612 LAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEA---SKGL 673
            ||.:|.|||||.||||:||.||:|:||:.||.:||.:|..||:.:|||||||||...|   ...|
 Worm   558 LATLDVMMGGRVAEELIFGDDKVTTGAADDLSKATQLAVQMVKVFGMSDKVGLRDFTAQDNESAL 622

  Fly   674 GTGDTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAILN 736
            .....|.|.|.|.:||||.|:|.:||:|||.||....:||:.||||||:||||.||::|.:::
 Worm   623 VKVSDLAPQTAELIDAEINRVLQESYKRAKVILETKKKEHQLLAEALLEYETLSADEVKRVIS 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	305/495 (62%)
ymel-1	NP_001366715.1	FtsH_fam	195..685	CDD:273520	305/494 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158519
Domainoid	1	1.000	222	1.000	Domainoid score	I1482
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31996
Inparanoid	1	1.050	603	1.000	Inparanoid score	I507
Isobase	1	0.950	-	0	Normalized mean entropy	S1086
OMA	1	1.010	-	-		QHG53805
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	1	1.000	-	-		FOG0003122
OrthoInspector	1	1.000	-	-		oto17613
orthoMCL	1	0.900	-	-		OOG6_101196
Panther	1	1.100	-	-	LDO	PTHR43655
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1955
SonicParanoid	1	1.000	-	-		X2093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	16	15.790