Protein Alignment YME1L and Spg7

DIOPT Version :10

• Sequence 1: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: XP_310523.6
• Gene: Spg7 / 1271665
• VectorBaseID: AGAMI1_008609
• Length: 790
• Species: Anopheles gambiae
• Alignment Length: 571
• Identity: 215/571 - (37%)
• Similarity: 307/571 - (53%)
• Gaps: 81/571 - (14%)

  Fly   208 EKLRRLLAKSEEHGFNKAESLKIAFAEGYLAAANSEDSPKSGKTM-KYLKTLQTIVVIVVFLG-- 269
            ||||     |.|......:.:.:.|             .:||... :.|.||....||:..|.
Mosquito   234 EKLR-----SVEQRLGVTDGVSVQF-------------ERSGDVSGRILFTLFATGVIIALLSRI 280

  Fly   270 ------IFLSFFTTSNGSVFRSIQLGNQVEVDPEEI---NVTFEDVKGCDEAKQELKEVVEFLKS 325
                  |.:..||....:.|        ..|||.|.   .|.|.||.|..|||||:.|.|::|||
Mosquito   281 RGGRGPISMDSFTQMGRAKF--------TLVDPVESGGRGVWFRDVAGLQEAKQEVMEFVDYLKS 337

  Fly   326 PEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFK 390
            |.::..||.|:|||.||:||||.||||||:|||.||:|||....|.||.|::.|.||.|||||||
Mosquito   338 PGRYQRLGAKVPKGALLLGPPGCGKTLLAKAVATEAQVPFLSMNGSEFIEMIGGLGAARVRDLFK 402

  Fly   391 AAKARAPCVIFIDEIDSVGAKR-----------TNSVLHPYANQTINQLLSEMDGFHQNAGVIVL 444
            .||.|:||:|::||||::|.:|           .||   ..:.||:||||.||||.....||::|
Mosquito   403 EAKKRSPCIIYVDEIDAIGRQREGGGGGGVGGGMNS---GESEQTLNQLLVEMDGMASKEGVLML 464

  Fly   445 GATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKILHDEIDL---DMLARGTSGFT 506
            .:|||.|.||:|||||||||..:::..|:...||||...:|:.|..:....   ..||..|.||:
Mosquito   465 ASTNRADILDKALLRPGRFDRHILIDLPNLAERKEIFEKHLSGIALEHPPATYSSRLATLTPGFS 529

  Fly   507 GADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVA 571
            |||:.|:.|:|||.||......|...:||.|.::::.|.|:::.........:.|:||.|||:|.
Mosquito   530 GADIANVCNEAALHAARTSQRVVRTSNLEYAVERLVGGTEKRSHALSPTERRVIAFHESGHALVG 594

  Fly   572 FYTKESHPLHKVTIMPR-GPSLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKIT 635
            :....|..|.||||:|| ..:||...|.|::::.: |:.||...|...:||||||.|.|  ::||
Mosquito   595 WMLPNSDVLLKVTIVPRTSLALGFAQYTPKEQKLY-TREQLFDKMCMALGGRAAENLTF--NRIT 656

  Fly   636 SGASSDLKQATSIATHMVRDWGMSDKVGLRTIEA------------SKGLGTGDTLGPNTIEAVD 688
            :||.:||::.|.:|...::.:||:..||......            |:|||          ..:|
Mosquito   657 TGAQNDLEKVTKMAYAQIKYFGMNSTVGPIAFAEDSDNSPYAEKPYSQGLG----------NLID 711

  Fly   689 AEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAILNESQ 739
            .|.:::::::|||.:.|||.:..:...||||||:.|||:.|.:..::...|
Mosquito   712 FEARKMITEAYERTEQILRDNADKLNRLAEALLEQETLNYDQVVELIGPPQ 762

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	HflB	258..737	CDD:440233	203/516 (39%)
Spg7	XP_310523.6	None