Protein Alignment YME1L and AFG3L2

DIOPT Version :9

• Sequence 1: NP_001246473.1
• Gene: YME1L / 37636
• FlyBaseID: FBgn0034792
• Length: 740
• Species: Drosophila melanogaster
• Sequence 2: NP_006787.2
• Gene: AFG3L2 / 10939
• HGNCID: 315
• Length: 797
• Species: Homo sapiens
• Alignment Length: 580
• Identity: 220/580 - (37%)
• Similarity: 324/580 - (55%)
• Gaps: 82/580 - (14%)

  Fly   201 GDTPLQAEKL-----------RRLLAKSEE---HGFNKAESLKIAFAEGYLAAANSEDSPKSGKT 251
            |.||:..:.:           |.|....:|   .|.|:...:.||.::|
Human   203 GKTPVDGQYVWFNIGSVDTFERNLETLQQELGIEGENRVPVVYIAESDG---------------- 251

  Fly   252 MKYLKTLQTIVVIVVFL-------------------GIFLSFFTTSNGSVFRSIQLGNQVEVDPE 297
             .:|.::...|:|:.||                   |:|....||:              :|..:
Human   252 -SFLLSMLPTVLIIAFLLYTIRRGPAGIGRTGRGMGGLFSVGETTA--------------KVLKD 301

  Fly   298 EINVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAK 362
            ||:|.|:||.||:|||.|:.|.|.|||:|:::.:||.|:|||.:|.|||||||||||:|.||||.
Human   302 EIDVKFKDVAGCEEAKLEIMEFVNFLKNPKQYQDLGAKIPKGAILTGPPGTGKTLLAKATAGEAN 366

  Fly   363 VPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAPCVIFIDEIDSVGAKRTNSVLHPYANQ--TI 425
            |||...:|.||.|:.||.|..||||||..|:..|||::||||||:||.||........:.|  |:
Human   367 VPFITVSGSEFLEMFVGVGPARVRDLFALARKNAPCILFIDEIDAVGRKRGRGNFGGQSEQENTL 431

  Fly   426 NQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGRFDVEVMVSTPDFTGRKEILSLYLTKI-L 489
            ||||.|||||:....|::|..|||.|.||.|||||||||.::.:..||..||..|..::|..: |
Human   432 NQLLVEMDGFNTTTNVVILAGTNRPDILDPALLRPGRFDRQIFIGPPDIKGRASIFKVHLRPLKL 496

  Fly   490 HDEIDLDMLARG----TSGFTGADLENMINQAALRAAIDGAETVSMKHLETARDKVLMGPERKAR 550
            ...::.|.|||.    |.||:|||:.|:.|:|||.||...:::::.||.|.|.::|:.|.|:|.:
Human   497 DSTLEKDKLARKLASLTPGFSGADVANVCNEAALIAARHLSDSINQKHFEQAIERVIGGLEKKTQ 561

  Fly   551 LPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPSLGHTAYIPEKERYHVTKAQLLAMM 615
            :...|.....||||.|||:..:|.:.:.||.||:|:|||..||:..|:| ||:|..||.|||..|
Human   562 VLQPEEKKTVAYHEAGHAVAGWYLEHADPLLKVSIIPRGKGLGYAQYLP-KEQYLYTKEQLLDRM 625

  Fly   616 DTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDWGMSDKVGLRTIEASKGLGTGDTL- 679
            ...:|||.:||:.||  :||:||..||::.|..|...:..:||::|||..:.:..:   .||.:
Human   626 CMTLGGRVSEEIFFG--RITTGAQDDLRKVTQSAYAQIVQFGMNEKVGQISFDLPR---QGDMVL 685

  Fly   680 ----GPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALLKYETLDADDIKAIL 735
                ...|...:|.|::.:::|:|:|..|:|.:...:.:.:|..||:.|.||.:|:..:|
Human   686 EKPYSEATARLIDDEVRILINDAYKRTVALLTEKKADVEKVALLLLEKEVLDKNDMVELL 745

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	209/513 (41%)
AFG3L2	NP_006787.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	76..126
		FtsH_ext	146..242	CDD:310823	8/38 (21%)
		TIP49	253..746	CDD:332389	209/513 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	759..797

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43655
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920