DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and YME1L1

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	NP_647473.1	Gene:	YME1L1 / 10730	HGNCID:	12843	Length:	773	Species:	Homo sapiens

Alignment Length:	599	Identity:	319/599 - (53%)
Similarity:	412/599 - (68%)	Gaps:	51/599 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 PLFSQQQLNQIRGFKTDRSIEAEQKRNPTMTSRLKNALANSPQRLDG----DTPLQAEKLRRLLA 215
            |:|.|.     |||||   :::..:|..:.:.||......:|..:.|    |.....|.|.:|:.
Human   200 PVFIQS-----RGFKT---LKSRTRRLQSTSERLAETQNIAPSFVKGFLLRDRGSDVESLDKLMK 256

  Fly   216 KS---EEHGFNKAESLKIAFAEGYLAAANSEDSPKSGKTMKYLKTLQTIVVIVVFLGI------- 270
            ..   |.|    .::.|..||||:|.|     ...:.||...|:..:.|:.:::..||
Human   257 TKNIPEAH----QDAFKTGFAEGFLKA-----QALTQKTNDSLRRTRLILFVLLLFGIYGLLKNP 312

  Fly   271 FLS--FFTTSNGSVFRSIQLGNQVEVDPEEI-NVTFEDVKGCDEAKQELKEVVEFLKSPEKFSNL 332
            |||  |.||:          |....|||.:: |||||.|||.:||||||:|||||||:|:||:.|
Human   313 FLSVRFRTTT----------GLDSAVDPVQMKNVTFEHVKGVEEAKQELQEVVEFLKNPQKFTIL 367

  Fly   333 GGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAAKARAP 397
            |||||||:|||||||||||||||||||||.|||::|:|.||||:.||.||.|:|:||:.|||.||
Human   368 GGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREAKANAP 432

  Fly   398 CVIFIDEIDSVGAKRTNSVLHPYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQALLRPGR 462
            |||||||:||||.||..|.:|||:.|||||||:|||||..|.|||::||||..:.||.||:||||
Human   433 CVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNALIRPGR 497

  Fly   463 FDVEVMVSTPDFTGRKEILSLYLTKILHDE-IDLDMLARGTSGFTGADLENMINQAALRAAIDGA 526
            ||::|.|..||..||.|||..||.||..|: :|.:::||||.||:||:|||::|||||:||:||.
Human   498 FDMQVTVPRPDVKGRTEILKWYLNKIKFDQSVDPEIIARGTVGFSGAELENLVNQAALKAAVDGK 562

  Fly   527 ETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIMPRGPS 591
            |.|:||.||.::||:||||||::...|.:..|||||||.||||:|:|||::.|::|.|||||||:
Human   563 EMVTMKELEFSKDKILMGPERRSVEIDNKNKTITAYHESGHAIIAYYTKDAMPINKATIMPRGPT 627

  Fly   592 LGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATHMVRDW 656
            |||.:.:||.:|::.|:|||||.||..||||.||||:||||.||:|||||...||.||..||..:
Human   628 LGHVSLLPENDRWNETRAQLLAQMDVSMGGRVAEELIFGTDHITTGASSDFDNATKIAKRMVTKF 692

  Fly   657 GMSDKVGLRTIEASKGLGTGDTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKALAEALL 721
            |||:|:|:.|..     .|| .|.|.|..|::.||:.:|.|||||||.||:.|.:|||.||||||
Human   693 GMSEKLGVMTYS-----DTG-KLSPETQSAIEQEIRILLRDSYERAKHILKTHAKEHKNLAEALL 751

  Fly   722 KYETLDADDIKAIL 735
            .||||||.:|:.:|
Human   752 TYETLDAKEIQIVL 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	291/493 (59%)
YME1L1	NP_647473.1	P-loop_NTPase	331..>395	CDD:304359	50/63 (79%)
		FtsH_fam	333..766	CDD:273520	277/439 (63%)
		AAA	375..506	CDD:278434	92/130 (71%)
		Peptidase_M41	586..764	CDD:279742	105/183 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165145131
Domainoid	1	1.000	207	1.000	Domainoid score	I2893
eggNOG	1	0.900	-	-		E1_COG0465
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31996
Inparanoid	1	1.050	571	1.000	Inparanoid score	I1057
Isobase	1	0.950	-	0	Normalized mean entropy	S1086
OMA	1	1.010	-	-		QHG53805
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	1	1.000	-	-		FOG0003122
OrthoInspector	1	1.000	-	-		oto89967
orthoMCL	1	0.900	-	-		OOG6_101196
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1955
SonicParanoid	1	1.000	-	-		X2093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.650