DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment YME1L and yme1l1

DIOPT Version :9

Sequence 1:	NP_001246473.1	Gene:	YME1L / 37636	FlyBaseID:	FBgn0034792	Length:	740	Species:	Drosophila melanogaster
Sequence 2:	XP_002933186.3	Gene:	yme1l1 / 100494966	XenbaseID:	XB-GENE-1000059	Length:	800	Species:	Xenopus tropicalis

Alignment Length:	734	Identity:	332/734 - (45%)
Similarity:	455/734 - (61%)	Gaps:	73/734 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 TKLHGSAGAARLSKSTSTSSRSHDLVLDLRNLLSRSSASIQ--GMVE-RAARLNGILDRRLVDDV 90
            |..|.....|....|.|..|...|:..|.....:..:.:::  |:.| |..:|:.|.|:
Frog   105 TAFHTPKTTAYFPSSASIQSLQRDVCPDQETHSNEPTFNLRDLGLSELRIKQLDKIFDQ------ 163

  Fly    91 LAKVTSMLPSMRDVRVTLEESATQIGRVQLQNYQFEVSLTGAAGSVPTGANVKVIPTITPGLLR- 154
                  :||.   :....::...|.....:....|..:..|.:|...|..:..::.. .|..|:
Frog   164 ------LLPG---IHTDKKKRPAQWHTSYVSAQSFFENKNGFSGVFNTLRSSSILRQ-QPSPLKL 218

  Fly   155 --------PLFSQQQLNQIRGFKTDRSIEAEQKRNPTMTSRLKNALANSPQRLDG----DTPLQA 207
                    |:|.|.     |||||   ::.:.:|..:.:.|:......:|..:.|    |.....
Frog   219 ICTDLQYWPVFIQS-----RGFKT---LKVKTRRLQSTSDRISEMENTAPSFMKGFLLRDRLPDV 275

  Fly   208 EKLRRLLAKSEEHGFNKAESLKIAFAEGYLAAANSEDSPKSGKTMKYLKTLQTIVVIVVFLGI-- 270
            :.|.:|: |::.......::.|..||||:|.|     ...:.:|...|:..:..:::::.|||
Frog   276 DNLDKLV-KNKNIPDGHQDAFKTGFAEGFLKA-----QALTQRTNDSLRRTRLFLLVLLLLGIYG 334

  Fly   271 -----FLS--FFTTSNGSVFRSIQLGNQVEVDPEEI-NVTFEDVKGCDEAKQELKEVVEFLKSPE 327
                 |||  |.|||          |....|||..: |||||.|||.:|||.||:|||||||:|:
Frog   335 LSKTPFLSVRFRTTS----------GLDASVDPIHMKNVTFEHVKGVEEAKHELQEVVEFLKNPQ 389

  Fly   328 KFSNLGGKLPKGVLLVGPPGTGKTLLARAVAGEAKVPFFHAAGPEFDEVLVGQGARRVRDLFKAA 392
            ||:.||||||||:|||||||||||||||||||||.|||::|:|.||||:.||.||.|:|:||:.|
Frog   390 KFTVLGGKLPKGILLVGPPGTGKTLLARAVAGEADVPFYYASGSEFDEMFVGVGASRIRNLFREA 454

  Fly   393 KARAPCVIFIDEIDSVGAKRTNSVLHPYANQTINQLLSEMDGFHQNAGVIVLGATNRRDDLDQAL 457
            |..|||||||||:||||.||..|.:|||:.|||||||:|||||..|.|||::||||..:.||.||
Frog   455 KGNAPCVIFIDELDSVGGKRIESPMHPYSRQTINQLLAEMDGFKPNEGVIIIGATNFPEALDNAL 519

  Fly   458 LRPGRFDVEVMVSTPDFTGRKEILSLYLTKILHD-EIDLDMLARGTSGFTGADLENMINQAALRA 521
            :||||||::|.|..||..||.|||..||:||..| .||.:::||||.||:||:|||::|||||:|
Frog   520 VRPGRFDMQVTVPRPDVKGRTEILKWYLSKIKFDVSIDPEIIARGTVGFSGAELENLVNQAALKA 584

  Fly   522 AIDGAETVSMKHLETARDKVLMGPERKARLPDEEANTITAYHEGGHAIVAFYTKESHPLHKVTIM 586
            |:||.:.|:||.||.|:||:||||||::...|.:..|||||||.|||::|:|||::.|::|.|||
Frog   585 AVDGKDMVTMKELEFAKDKILMGPERRSVEIDSKNKTITAYHESGHAVIAYYTKDAMPINKATIM 649

  Fly   587 PRGPSLGHTAYIPEKERYHVTKAQLLAMMDTMMGGRAAEELVFGTDKITSGASSDLKQATSIATH 651
            ||||:|||.:.:||.:|:..|::||||.||..||||.|||::||:|:||:|||||...||.||..
Frog   650 PRGPTLGHVSLLPENDRWSETRSQLLAQMDVSMGGRVAEEIIFGSDQITTGASSDFDSATQIAKL 714

  Fly   652 MVRDWGMSDKVGLRTIEASKGLGTGDTLGPNTIEAVDAEIKRILSDSYERAKAILRKHTREHKAL 716
            ||..:|||:|:|:.|..     .|| .|.|.|..|::.|::.:|.:||||||.||:.|.:|||.|
Frog   715 MVTRFGMSEKLGVMTYS-----DTG-KLSPETQAAIEQEVRTLLKESYERAKNILKTHAKEHKNL 773

  Fly   717 AEALLKYETLDADDIKAIL 735
            |||||.||||||.:|:.:|
Frog   774 AEALLMYETLDAKEIQVVL 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
YME1L	NP_001246473.1	FtsH_fam	254..736	CDD:273520	285/493 (58%)
yme1l1	XP_002933186.3	FtsH_fam	360..793	CDD:273520	270/439 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	201	1.000	Domainoid score	I2954
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31996
Inparanoid	1	1.050	561	1.000	Inparanoid score	I1082
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D217929at2759
OrthoFinder	1	1.000	-	-		FOG0003122
OrthoInspector	1	1.000	-	-		oto103777
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1955
SonicParanoid	1	1.000	-	-		X2093
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.090