DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment EMC8-9 and EMC9

DIOPT Version :9

Sequence 1:	NP_611731.1	Gene:	EMC8-9 / 37635	FlyBaseID:	FBgn0034791	Length:	203	Species:	Drosophila melanogaster
Sequence 2:	NP_057133.2	Gene:	EMC9 / 51016	HGNCID:	20273	Length:	208	Species:	Homo sapiens

Alignment Length:	199	Identity:	78/199 - (39%)
Similarity:	107/199 - (53%)	Gaps:	13/199 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MCDYKVSERAYAKLIFHAAKYPHQAVNGLLLAEKTSKGSQVEIVDAIPLFHQCLYVTPMAEVALM 65
            |.:.::|..||.|:..|||:|||.|||||.||.....|..:.:.|.:||||..|.::.|.||||.
Human     1 MGEVEISALAYVKMCLHAARYPHAAVNGLFLAPAPRSGECLCLTDCVPLFHSHLALSVMLEVALN 65

  Fly    66 LIDAHAEREGLVIAGYYAAPENFYDNQVDKTP---AAKIADKIQENFKNACFVVVDNKLMTLQHD 127
            .:|....:.|||:||||.|  |...|  |::|   |.|||.:|.|.|.:|..:::||:.:..|..
Human    66 QVDVWGAQAGLVVAGYYHA--NAAVN--DQSPGPLALKIAGRIAEFFPDAVLIMLDNQKLVPQPR 126

  Fly   128 RAAIQVFNCPGDSGARWSKAKFTLSQASDTLEG---VSLLLKRGAMRDLVDFDNHLDNPDKNWTN 189
            ...:.|..   :.|.||......|....|..|.   |..||:..|.:.|||||.|||:..::|||
Human   127 VPPVIVLE---NQGLRWVPKDKNLVMWRDWEESRQMVGALLEDRAHQHLVDFDCHLDDIRQDWTN 188

  Fly   190 DFLN 193
            ..||
Human   189 QRLN 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
EMC8-9	NP_611731.1	UPF0172	3..188	CDD:281640	72/190 (38%)
EMC9	NP_057133.2	MPN_UPF0172	6..188	CDD:163691	73/188 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141576
Domainoid	1	1.000	115	1.000	Domainoid score	I6030
eggNOG	1	0.900	-	-		E1_KOG3289
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41095
Inparanoid	1	1.050	117	1.000	Inparanoid score	I4810
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54791
OrthoDB	1	1.010	-	-		D1284861at2759
OrthoFinder	1	1.000	-	-		FOG0002590
OrthoInspector	1	1.000	-	-		otm41865
orthoMCL	1	0.900	-	-		OOG6_102725
Panther	1	1.100	-	-	LDO	PTHR12941
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4556
SonicParanoid	1	1.000	-	-		X2308
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800