Protein Alignment PIP5K59B and PIP5K1A

DIOPT Version :9

• Sequence 1: NP_001369113.1
• Gene: PIP5K59B / 37633
• FlyBaseID: FBgn0034789
• Length: 891
• Species: Drosophila melanogaster
• Sequence 2: XP_006711626.1
• Gene: PIP5K1A / 8394
• HGNCID: 8994
• Length: 574
• Species: Homo sapiens
• Alignment Length: 552
• Identity: 287/552 - (51%)
• Similarity: 364/552 - (65%)
• Gaps: 81/552 - (14%)

  Fly    57 RKIGHRRVGEGGEITYKKIQTSQIMGSIQLGIQHTVGSLASKPKRDLLMMDFWEIESITFPPEGS 121
            :|||||.|...||.||||..:|.:.|:|||||.||||||::||:||:||.||:.:|||.||.|||
Human    74 KKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIFFPSEGS 138

  Fly   122 SLTPAHHYSEFRYKIYAPIAFRYFRDLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYLTTDDEF 186
            :|||||||::||:|.|||:||||||:||||:|||::.|:|:.||.||.:.|||||:||:::||||
Human   139 NLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASGSLFYVSSDDEF 203

  Fly   187 IIKTVQHKEGEFLQKLLPGYYMNLNQNPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSVKMH 251
            |||||||||.|||||||||||||||||||||||||:||||:| :..||||:||||||||.|||||
Human   204 IIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQ-AGGKNIRIVVMNNLLPRSVKMH 267

  Fly   252 LKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTVLESFKI 316
            :||||||||:||:|::.||.|..||:|||||::..|:|:||:|:.|.||.||:||||.||:||||
Human   268 IKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADMYNALCKTLQRDCLVLQSFKI 332

  Fly   317 MDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGDAATGISRNKSVNRQRLVAH 381
            ||||||:.:||:|.|.:|                       ||..:....:...:...::.|  :
Human   333 MDYSLLMSIHNIDHAQRE-----------------------PLSSETQYSVDTRRPAPQKAL--Y 372

  Fly   382 STAMESIQAESEPIDD-EEDVPPGGIPARSEKGERLLLYIGIIDILQSYRLKKKLEHTFKSIIHD 445
            ||||||||.|:..... |.|...||||||:.|||||||||||||||||||..|||||::|:::||
Human   373 STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWKALVHD 437

  Fly   446 GETVSVCRPSFYAQRFQNFMAKTVFRKIPSLDLPEIKGNHRKFRTLVTSYIALKHSPSKR-KSLS 509
            |:||||.||.|||:|||.||..|||:|||                       ||.||||: :|.|
Human   438 GDTVSVHRPGFYAERFQRFMCNTVFKKIP-----------------------LKPSPSKKFRSGS 479

  Fly   510 KAIQRSIDSDNEVASRPVHASHSHSSGKIHQPAKPPTTEPTPAGAAGGAERGATALGPATTSGAS 574
            ...:|:..|.|...:.....|..|.:    |.......||       |...|...:.|.|
Human   480 SFSRRAGSSGNSCITYQPSVSGEHKA----QVTTKAEVEP-------GVHLGRPDVLPQT----- 528

  Fly   575 ERAPPPVKQRTPAASNLKTRVPPPVP-PRGSP 605
                ||:::.:..:         |:| |..||
Human   529 ----PPLEEISEGS---------PIPDPSFSP 547

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	245/395 (62%)
PIP5K1A	XP_006711626.1	PIPKc	121..461	CDD:214623	225/365 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147745
Domainoid	1	1.000	363	1.000	Domainoid score	I945
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H93492
Inparanoid	1	1.050	523	1.000	Inparanoid score	I1259
Isobase	1	0.950	-	0	Normalized mean entropy	S1569
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		mtm8523
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	LDO	PTHR23086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2198
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.740