DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP5K59B and Pip5kl1

DIOPT Version :9

Sequence 1:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_038962106.1	Gene:	Pip5kl1 / 687758	RGDID:	1597527	Length:	606	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	109/487 - (22%)
Similarity:	193/487 - (39%)	Gaps:	107/487 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASGDGDTINTIDMDSSSASQAKLAEPSNAS----TDHVGNSSPDLGNRPNRASSKAD-------K 55
            |..:.|:.|    .:|..:|.||...:.|:    :..:.:.|.|:|||...:.|:..       |
  Rat   189 AEAEPDSCN----PASEPNQEKLHLGAMAALSLGSREIPSHSLDVGNRSTSSGSRRGLFWHLRAK 249

  Fly    56 ERKIGHRRVGEGGEITYKKIQTSQIMGSIQLGI-QHTVGSLASKPKRDLLMMDFWEIESITFPPE 119
            ..::|...:|.|.|:       .::...:|.|: ..|..|:.:.|.......||.|:
  Rat   250 HSRVGLFEIGPGHEL-------HRMTRMMQEGLWAATQVSMNNPPTGPPTQKDFLEV-------- 299

  Fly   120 GSSLTPAHHYSEFRYKIYAPIAFRYFRDLFGIQPDDFMMSMCT-SPLRELSNPGASGSIFYLTTD 183
               :|..|. ..|.....|..||...|...|:..:|:..::.. .|..:..:...|.:.|:|:.|
  Rat   300 ---MTQVHK-EGFELGTLAGPAFARLRQSIGLTEEDYQATLGPGDPYLQFLSTSKSKASFFLSHD 360

  Fly   184 DEFIIKTVQHKEGEFLQKLLPGYYMNLNQNPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSV 248
            ..|.:||.:.:|.:.|...||.|..:|.|.|.:||.:..|:|.|:.:..|....::|..:...:.
  Rat   361 QRFFVKTQRRQEVQVLLAHLPRYVRHLQQYPHSLLARLLGVYSLRVAQGKKKYFIIMQCIFYPTS 425

  Fly   249 KMHLKYDLKGSTFKRKANKAERAKKSP---TYKDLDFMEQHPNGIFLEAETYAA-LIKTIQRDCT 309
            ::..:||:||....|..:.....  ||   ..|||:|.|:     .::..|..: .::.:..|..
  Rat   426 RISERYDIKGCEVSRWVDPVPEG--SPLLLVLKDLNFREK-----TIKLGTQRSWFLRQMALDTA 483

  Fly   310 VLESFKIMDYSLLLGV-----------HNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGDA 363
            .|....::|||||:||           |.|...:|..|.       ||.:|:.|
  Rat   484 FLRELNVLDYSLLVGVQFLHKDEKVDYHCLIGTIKSVQG-------APKSENKD----------- 530

  Fly   364 ATGISRNKSVNRQRLVAHSTAMESIQAESEPIDDEEDVPPGGIPARSEKGERLLLYIGIIDILQS 428
                    ..||:.|.....|:..:.                       |.....::|::|:...
  Rat   531 --------GQNRRMLPNLPNALHIVD-----------------------GPDQRYFLGLVDLTTV 564

  Fly   429 YRLKKKLEHTFKSIIHDGETVSVCRPSFYAQR 460
            |..:|:|||.:|.:.:.|::||...|:.||:|
  Rat   565 YGFRKRLEHLWKMVRYPGQSVSTVSPAHYARR 596

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	90/400 (23%)
Pip5kl1	XP_038962106.1	PHA03307	16..>203	CDD:223039	4/17 (24%)
Pip5kl1	XP_038962106.1	PIPKc_PIP5KL1	262..604	CDD:340441	91/410 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010