DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP5K59B and pip5k1ab

DIOPT Version :9

Sequence 1:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_021322354.1	Gene:	pip5k1ab / 492549	ZFINID:	ZDB-GENE-041111-123	Length:	598	Species:	Danio rerio

Alignment Length:	601	Identity:	294/601 - (48%)
Similarity:	374/601 - (62%)	Gaps:	95/601 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 SKADKERKIGHRRVGEGGEITYKKIQTSQIMGSIQLGIQHTVGSLASKPKRDLLMMDFWEIESIT 115
            |....::.||||.|...||.||||..:|.:.|:|||||.||||||:.|.:||:||.||:.:|||.
Zfish    45 SSQSMKKTIGHRGVDPTGETTYKKTTSSALKGAIQLGIAHTVGSLSQKAERDVLMQDFYVVESIF 109

  Fly   116 FPPEGSSLTPAHHYSEFRYKIYAPIAFRYFRDLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYL 180
            ||.|||:||||||:.:||:|.||||||||||:||||:|||::.|:|..||.|||||||||||||:
Zfish   110 FPSEGSNLTPAHHHGDFRFKTYAPIAFRYFRELFGIRPDDYLYSLCNDPLIELSNPGASGSIFYV 174

  Fly   181 TTDDEFIIKTVQHKEGEFLQKLLPGYYMNLNQNPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLP 245
            |:|||||||||.|||.||||||||||:||||||.|||||||:||||:| :..||||:||||||||
Zfish   175 TSDDEFIIKTVMHKEAEFLQKLLPGYFMNLNQNKRTLLPKFYGLYCVQ-AGGKNIRIVVMNNLLP 238

  Fly   246 SSVKMHLKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTV 310
            .||.|||||||||||:||:|:..||.|..||||||||::..|.||.||.:.|.||.|||||||.:
Zfish   239 RSVPMHLKYDLKGSTYKRRASPKERDKSVPTYKDLDFIQDMPEGIQLEPDNYNALCKTIQRDCLL 303

  Fly   311 LESFKIMDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGDAATGISRNKSVNR 375
            |:||||||||||:||||.|:|.:|         ||.:.|..         |...|....::....
Zfish   304 LQSFKIMDYSLLVGVHNTDLASRE---------RAGVVEGG---------GSEGTVTPDHRRPQI 350

  Fly   376 QRLVAHSTAMESIQAESE---PIDDEEDVPPGGIPARSEKGERLLLYIGIIDILQSYRLKKKLEH 437
            |:.: :||||||||.|::   .::.|:..  ||||||:.:|||:|:||||||||||||..|||||
Zfish   351 QKAL-YSTAMESIQGEAKGKGTLETEDQW--GGIPARNSRGERILVYIGIIDILQSYRFIKKLEH 412

  Fly   438 TFKSIIHDGETVSVCRPSFYAQRFQNFMAKTVFRKIPSLDLPEIKGNHRKFRTLVTSYIALKHSP 502
            ::|:::|||:||||.||.|||:|||.||..|||:|                        .||.||
Zfish   413 SWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKK------------------------TLKSSP 453

  Fly   503 SK--RKSLSKAIQR-------SIDSDNEVA-SRPVHASHSHS---SGKIHQPAKPPTTEPTPAGA 554
            ||  |...|..::|       |......:| :|.|:.:|.:.   .|:...|:..|...|.....
Zfish   454 SKKSRSGCSSVVRRLPMGSTASAPGSQTLADARLVYRTHLNQPDLEGESGMPSDRPDLLPQTDPL 518

  Fly   555 AGGAERGATALGPATTSGASERAPPPVKQRTPAASNLKTRVPPPVPPRGSPRRKDAQDRTTPGTE 619
            ||               .:||.|...|...:|.::.:.:..||               :.:.|.|
Zfish   519 AG---------------SSSEFAATNVSCSSPGSTRMTSSSPP---------------QRSVGVE 553

  Fly   620 PH---TTNPNPAPAHT 632
            .|   .|.|:.:..|:
Zfish   554 VHKSAVTEPDNSTLHS 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	248/397 (62%)
pip5k1ab	XP_021322354.1	PIPKc	98..444	CDD:214623	229/367 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581580
Domainoid	1	1.000	372	1.000	Domainoid score	I849
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H93492
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1176
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		mtm6440
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	LDO	PTHR23086
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.760