DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PIP5K59B and pip4k2ca

DIOPT Version :9

Sequence 1:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_956395.2	Gene:	pip4k2ca / 373124	ZFINID:	ZDB-GENE-030828-9	Length:	416	Species:	Danio rerio

Alignment Length:	451	Identity:	127/451 - (28%)
Similarity:	214/451 - (47%)	Gaps:	61/451 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 VGNSSPDLGNRPNRASSKADKERKIGHRRVGEGGEITYKKIQTSQIMGSIQL-GIQHTVGSLASK 98
            :|||..........|.....|:|....::|        |..:.|..|.|:.: |:.|::..|...
Zfish     4 LGNSGSASSPMVMLAPKTKTKKRHFMQQKV--------KVFRASDPMLSVFMWGVNHSINDLNQV 60

  Fly    99 PKRDLLMMDFW------EIESITFPPEGSSLTPAHHYSEFRYKIYAPIAFRYFRDLFGIQPDDFM 157
            |...:|:.|.:      ::.:..|..|.   .|:|    |.:|.|.|..||..|:.|||:..|:.
Zfish    61 PVPVMLLPDDFKANTKIKVNNHLFNKEN---LPSH----FEFKEYCPQVFRNLRERFGIEDLDYQ 118

  Fly   158 MSMCTS-PLRELSNPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLLPGYYMNLNQ-NPRTLLPK 220
            .|:..| |::   ..|....:.:.:.|...|:|.:..:|...:..:|..|:.::.: :..||||:
Zfish   119 ASLARSAPMK---GDGQGEGLLFTSYDRTLIVKQISSEEVADMHNILSEYHQHIVKCHGSTLLPQ 180

  Fly   221 FFGLYCLQTSNAKNIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQ 285
            |.|:|.: |..:::..|:||.|:....:.:|.|||||||...|:|:..|:.|:.||:||:|| ..
Zfish   181 FLGMYRI-TVESEDTYLIVMRNMFSHRLLVHRKYDLKGSLVDREASDKEKVKELPTFKDMDF-RN 243

  Fly   286 HPNGIFLEAETYAALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAED 350
            :...:::..|....:::.:.||...|...||||||||||:|  |||..|::.|:.:   .|..||
Zfish   244 NMQKVYVTEEQKEKMMEKLNRDVEFLVKLKIMDYSLLLGIH--DVARGEREEEEAE---EPCYED 303

  Fly   351 SDVDADDPLDGDAATGISRNKSVNRQRLVAHSTAMESIQAESEPIDDEEDVPPGGI-------PA 408
                     |.|...|::....|.     ::.|:.|.|......|   :.:.||..       ..
Zfish   304 ---------DADPENGLAPALQVG-----SYGTSPEGIAGYMNSI---KPLGPGEFDPYIDVYAV 351

  Fly   409 RSEKG--ERLLLYIGIIDILQSYRLKKKLEHTFKSIIHD-GETVSVCRPSFYAQRFQNFMA 466
            :|..|  :|.:.::|:||:|..|..|||..|..|::.|. |..:|...|..||:||:.|::
Zfish   352 KSAPGAPQREVYFMGLIDVLTQYDTKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFREFIS 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	119/408 (29%)
pip4k2ca	NP_956395.2	PIPKc	67..415	CDD:214623	111/380 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920