DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP5K59B and Pip5k1a

DIOPT Version :9

Sequence 1:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_038958707.1	Gene:	Pip5k1a / 365865	RGDID:	1306127	Length:	561	Species:	Rattus norvegicus

Alignment Length:	575	Identity:	290/575 - (50%)
Similarity:	369/575 - (64%)	Gaps:	94/575 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 GNRPNRASSKADKE--------------RKIGHRRVGEGGEITYKKIQTSQIMGSIQLGIQHTVG 93
            |.|..||::...|.              :|||||.|...||.||||..:|.:.|:|||||.||||
  Rat    33 GVRRKRAAASGIKRGTVSEGPYASLMPVKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVG 97

  Fly    94 SLASKPKRDLLMMDFWEIESITFPPEGSSLTPAHHYSEFRYKIYAPIAFRYFRDLFGIQPDDFMM 158
            ||::||:||:||.||:.:|||.||.|||:|||||||::||:|.|||:||||||:||||:|||::.
  Rat    98 SLSTKPERDVLMQDFYVVESIFFPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLY 162

  Fly   159 SMCTSPLRELSNPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLLPGYYMNLNQNPRTLLPKFFG 223
            |:|:.||.||||.|||||:||:::|||||||||||||.|||||||||||||||||||||||||:|
  Rat   163 SLCSEPLIELSNSGASGSLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYG 227

  Fly   224 LYCLQTSNAKNIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQHPN 288
            |||:| :..||||:||||||||.|||||:||||||||:||:|::.||.|..||:|||||::..|:
  Rat   228 LYCVQ-AGGKNIRIVVMNNLLPRSVKMHMKYDLKGSTYKRRASQKEREKTLPTFKDLDFLQDIPD 291

  Fly   289 GIFLEAETYAALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDV 353
            |:||:|:.|:||.||:||||.||:||||||||||:.:||:|.|.:|
  Rat   292 GLFLDADMYSALCKTLQRDCLVLQSFKIMDYSLLMSIHNMDHAQRE------------------- 337

  Fly   354 DADDPLDGDAATGISRNKSVNRQRLVAHSTAMESIQAESE---PIDDEEDVPPGGIPARSEKGER 415
                |::.:....|...:...::.|  :||||||||.|:.   .::.|:.:  ||||||:.||||
  Rat   338 ----PMNSETQYSIDTRRPAPQKAL--YSTAMESIQGEARRGGTVETEDHM--GGIPARNNKGER 394

  Fly   416 LLLYIGIIDILQSYRLKKKLEHTFKSIIHDGETVSVCRPSFYAQRFQNFMAKTVFRKIPSLDLPE 480
            |||||||||||||||..|||||::|:::|||:||||.||.|||:|||.||..|||:|||
  Rat   395 LLLYIGIIDILQSYRFVKKLEHSWKALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIP------ 453

  Fly   481 IKGNHRKFRTLVTSYIALKHSPSKRKSLSKAIQRSIDSDNEVASRPVHASHSHSSGKIHQPAKPP 545
                             ||.||:|:                ..|.|..:..|..||....|
  Rat   454 -----------------LKPSPTKK----------------FRSGPSFSRRSGPSGNSCTP---- 481

  Fly   546 TTEPTPAGAAGGAERGATALGPATTSGASERAPPPVKQRTPAASNLKTRVPPPVP 600
             ::||.:|     |..|.....|..........|.|..:||....:....|.|.|
  Rat   482 -SQPTASG-----EHKAQVTTKAEVEPDIHLGRPDVLPQTPPLEEISEGSPVPGP 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	246/397 (62%)
Pip5k1a	XP_038958707.1	PIPKc_PIP5K1A_like	79..454	CDD:340443	249/425 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341574
Domainoid	1	1.000	363	1.000	Domainoid score	I912
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H93492
Inparanoid	1	1.050	496	1.000	Inparanoid score	I1334
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		mtm8996
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	LDO	PTHR23086
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760