DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP5K59B and PIP5K1C

DIOPT Version :9

Sequence 1:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_011526147.1	Gene:	PIP5K1C / 23396	HGNCID:	8996	Length:	731	Species:	Homo sapiens

Alignment Length:	718	Identity:	326/718 - (45%)
Similarity:	420/718 - (58%)	Gaps:	142/718 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SSSASQAKLAEPSNASTDHVG-NSSPDLGNRPNRASSKADKERKIGHRRVGEGGEITYKKIQTSQ 79
            :.|.:.|.||:...|.|:.:. .:.|..|:           .:|:|||.|...||.||||..:|.
Human    25 AESGAAAGLAQKKAAPTEVLSMTAQPGPGH-----------GKKLGHRGVDASGETTYKKTTSST 78

  Fly    80 IMGSIQLGIQHTVGSLASKPKRDLLMMDFWEIESITFPPEGSSLTPAHHYSEFRYKIYAPIAFRY 144
            :.|:|||||.:|||.|:|||:||:||.||:.:|||.||.|||:||||||:.:||:|.|||:||||
Human    79 LKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVAFRY 143

  Fly   145 FRDLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLLPGYYMN 209
            ||:||||:|||::.|:|..||.||||||||||:||:|:|||||||||.|||.|||||||||||||
Human   144 FRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMN 208

  Fly   210 LNQNPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANKAERAKKS 274
            ||||||||||||:||||:| |..||||:|||||:||..||||||:||||||:||:|:|.|:.|..
Human   209 LNQNPRTLLPKFYGLYCVQ-SGGKNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSF 272

  Fly   275 PTYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQ 339
            |||||||||:..|.|:.|:|:|::||:||:||||.||||||||||||||||||:|...:|:|::
Human   273 PTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLLLGVHNIDQHERERQAQ- 336

  Fly   340 RKPLRAPLAEDSDVDADDPLDGDAATGISRNKSVNRQRLVAHSTAMESIQ---AESEPIDDEEDV 401
                                 |..:|. ...:.|.::.|  :||||||||   |..|.|:.::.:
Human   337 ---------------------GAQSTS-DEKRPVGQKAL--YSTAMESIQGGAARGEAIESDDTM 377

  Fly   402 PPGGIPARSEKGERLLLYIGIIDILQSYRLKKKLEHTFKSIIHDGETVSVCRPSFYAQRFQNFMA 466
              |||||.:.:||||||:|||||||||||..||||||:|:::|||:||||.||||||:||..||:
Human   378 --GGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALVHDGDTVSVHRPSFYAERFFKFMS 440

  Fly   467 KTVFRKIPSLDLPEIKGNHRKFRTLVTSYIALKHSPSKR---------KSLSKAIQRS---IDSD 519
            .|||||..|                      ||.||||:         |.|......|   |.|:
Human   441 NTVFRKNSS----------------------LKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSE 483

  Fly   520 NEVASRPVHASHSHSSGKIHQPAKP---PTTEPTPAGAAGGAERGATALGPATTSGAS----ERA 577
            .|.|...:..:.|:.:  :....:|   |.|.|:       .|...||....|.|..|    ||:
Human   484 REEAQYDLRGARSYPT--LEDEGRPDLLPCTPPS-------FEEATTASIATTLSSTSLSIPERS 539

  Fly   578 P------PPVKQRT-------------PAASNLKTRVPPPVPPRGS-----PRRKDAQDRTTPGT 618
            |      |..::||             ||..:|: ::...|.|..|     |:.:||      |.
Human   540 PSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQ-QITVQVEPACSVEIVVPKEEDA------GV 597

  Fly   619 EPHTTNPNPAPAHTHTLQVPANEGIPRFGDRRSPSNVQDWLELHDLFDGPDSGPY-----GPYAP 678
            |......:.|.......|....||.|.             .:..|..|.|.:..|     ||:||
Human   598 EASPAGASAAVEVETASQASDEEGAPA-------------SQASDEEDAPATDIYFWRLWGPHAP 649

  Fly   679 PAP 681
            ..|
Human   650 TWP 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	250/397 (63%)
PIP5K1C	XP_011526147.1	PIPKc	103..443	CDD:214623	230/367 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	363	1.000	Domainoid score	I945
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	523	1.000	Inparanoid score	I1259
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		mtm8523
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	O	PTHR23086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2198
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.860