Protein Alignment PIP5K59B and Pip5k1c

DIOPT Version :10

• Sequence 1: NP_001369113.1
• Gene: PIP5K59B / 37633
• FlyBaseID: FBgn0034789
• Length: 891
• Species: Drosophila melanogaster
• Sequence 2: NP_001280575.1
• Gene: Pip5k1c / 18717
• MGIID: 1298224
• Length: 687
• Species: Mus musculus
• Alignment Length: 678
• Identity: 314/678 - (46%)
• Similarity: 408/678 - (60%)
• Gaps: 131/678 - (19%)

  Fly    57 RKIGHRRVGEGGEITYKKIQTSQIMGSIQLGIQHTVGSLASKPKRDLLMMDFWEIESITFPPEGS 121
            :|:|||.|...||.||||..:|.:.|:|||||.:|||:|:|||:||:||.||:.:|||.||.|||
Mouse    56 KKLGHRGVDASGETTYKKTTSSTLKGAIQLGIGYTVGNLSSKPERDVLMQDFYVVESIFFPSEGS 120

  Fly   122 SLTPAHHYSEFRYKIYAPIAFRYFRDLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYLTTDDEF 186
            :||||||:.:||:|.|||:||||||:||||:|||::.|:|..||.||||||||||:||:|:||||
Mouse   121 NLTPAHHFQDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSVFYVTSDDEF 185

  Fly   187 IIKTVQHKEGEFLQKLLPGYYMNLNQNPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSVKMH 251
            |||||.|||.|||||||||||||||||||||||||:||||:| |..||||:|||||:||..||||
Mouse   186 IIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQ-SGGKNIRVVVMNNVLPRVVKMH 249

  Fly   252 LKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTVLESFKI 316
            ||:||||||:||:|:|.|:.|..|||||||||:..|.|:.|:::|:.||:||:||||.|||||||
Mouse   250 LKFDLKGSTYKRRASKKEKEKSLPTYKDLDFMQDMPEGLLLDSDTFGALVKTLQRDCLVLESFKI 314

  Fly   317 MDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGDAATGISRNKSVNRQRLVAH 381
            |||||||||||:|...:|:|           ||.:...||:            .:.|.::.|  :
Mouse   315 MDYSLLLGVHNIDQQERERQ-----------AEGAQSKADE------------KRPVAQKAL--Y 354

  Fly   382 STAMESIQ---AESEPIDDEEDVPPGGIPARSEKGERLLLYIGIIDILQSYRLKKKLEHTFKSII 443
            ||||||||   |..|.|:.::.:  |||||.:.:||||||:|||||||||||..||||||:|:::
Mouse   355 STAMESIQGGAARGEAIETDDTM--GGIPAVNGRGERLLLHIGIIDILQSYRFIKKLEHTWKALV 417

  Fly   444 HDGETVSVCRPSFYAQRFQNFMAKTVFRKIPSLDLPEIKGNHRKFRTLVTSYIALKHSPSKR--- 505
            |||:||||.||||||:||..||:.|||||..|                      ||.||||:
Mouse   418 HDGDTVSVHRPSFYAERFFKFMSSTVFRKSSS----------------------LKSSPSKKGRG 460

  Fly   506 -----KSLSKAIQRS---IDSDNEVASRPVHASHSHSSGKIHQPAKP---PTTEPTPAGAAGGAE 559
                 |.|......|   |.|:.|.....:..:.|:.:  :....:|   |.|.|:       .|
Mouse   461 ALLAVKPLGPTAAFSASQIPSEREDVQYDLRGARSYPT--LEDEGRPDLLPCTPPS-------FE 516

  Fly   560 RGATALGPATTSGAS----ERAP------PPVKQRT------------PAASNLK---TRVPP-- 597
            ...||....|.|..|    ||:|      |..::||            |.|.:|:   .:|.|
Mouse   517 EATTASIATTLSSTSLSIPERSPSDTSEQPRYRRRTQSSGQDGRPQEEPHAEDLQKITVQVEPVC 581

  Fly   598 -------------PVPPRGSPRRKDAQ-DRTTPGTEPHTTNPNPAPAHTHTLQVPANEGIPRFGD 648
                         .|||.|:......: |..:..:||.:...:...|.:..:...|:.....|..
Mouse   582 GVGVVPKEEGAGVEVPPCGASAAASVEIDAASQASEPASQASDEEDAPSTDIYFFAHGRYWLFSP 646

  Fly   649 RR------------SPSNVQDWL--ELH 662
            ||            :|::.:.|:  .||
Mouse   647 RRRQLRAVTPNHTGTPTDERSWVYSPLH 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	251/397 (63%)
Pip5k1c	NP_001280575.1	PIPKc_PIP5K1C	76..449	CDD:340445	252/400 (63%)