DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP5K59B and Pikfyve

DIOPT Version :9

Sequence 1:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_006495839.1	Gene:	Pikfyve / 18711	MGIID:	1335106	Length:	2109	Species:	Mus musculus

Alignment Length:	508	Identity:	113/508 - (22%)
Similarity:	186/508 - (36%)	Gaps:	154/508 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 NTIDMDSSSASQAKLAEPSNASTDHVGNSSPD---------------LGNRPNRASSKADKERKI 59
            :.:|....|:|..:|.|.|...|:....:.|.               .|..|:.:|.|.:..|
Mouse  1715 SALDNRPKSSSPIRLPEISGGQTNRTVEAEPQPTKKASGMLSFFRGTAGKSPDLSSQKRETLR-- 1777

  Fly    60 GHRRVGEGGEITYKKIQTSQIMGSIQLGIQHTVGSLASKPKRDLLMMDFWEIESITFPPEGSSLT 124
                   |.:..|.::..:...|....|::         |:.::...| .:.:.:|.|......:
Mouse  1778 -------GADSAYYQVGQAGKEGLESQGLE---------PQDEVDGGD-TQKKQLTNPHVELQFS 1825

  Fly   125 PAHHYSEFRYKIYAPIAFRYFRD-LFGIQPDDFMMSMC-TSPLRELSNPGASGSIFYLTTDDEFI 187
            .|:  ::|..::|....|...|: :.|...::|:.|:. :||.:  :..|.||:.||.|.||.||
Mouse  1826 DAN--AKFYCRLYYAGEFHKMREVILGSSEEEFIRSLSHSSPWQ--ARGGKSGAAFYATEDDRFI 1886

  Fly   188 IKTVQHKEGEFLQKLLPGYY---MNLNQNPR-TLLPKFFGLYCL-----QTSNAKNIRLVVMNNL 243
            :|.:...|.:......|.|:   .|..|..| |.|.|..|:|.:     |.:..|.:.|:||.||
Mouse  1887 LKQMPRLEVQSFLDFAPHYFNYITNAVQQKRPTALAKILGVYRIGYKNSQNNTEKKLDLLVMENL 1951

  Fly   244 LPSSVKMHLKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQH------PNGIFLEAETYAALIK 302
            .... ||...:|||||...|.. |.:..|:|   .|:..::::      .|.:::.:.:.:.|..
Mouse  1952 FYGR-KMAQVFDLKGSLRNRNV-KTDTGKES---CDVVLLDENLLKMVRDNPLYIRSHSKSVLRT 2011

  Fly   303 TIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGDAATGI 367
            :|..|...|.|..|:|||||:|                              .||
Mouse  2012 SIHSDAHFLSSHLIIDYSLLVG------------------------------RDD---------- 2036

  Fly   368 SRNKSVNRQRLVAHSTAMESIQAESEPIDDEEDVPPGGIPARSEKGERLLLYIGIIDILQSYRLK 432
                           |:.|                               |.:||||.::::...
Mouse  2037 ---------------TSNE-------------------------------LVVGIIDYIRTFTWD 2055

  Fly   433 KKLEHTFKS---IIHDGETVSVCRPSFYAQRFQNFMAKTVFRKIP----SLDL 478
            ||||...||   :...|:..:|..|..|..||...|.| .|..:|    .|||
Mouse  2056 KKLEMVVKSTGILGGQGKMPTVVSPELYRTRFCEAMDK-YFLMVPDHWTGLDL 2107

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	94/414 (23%)
Pikfyve	XP_006495839.1	FYVE_PIKfyve_Fab1	166..227	CDD:277264
		DEP_PIKfyve	369..450	CDD:239895
		Fab1_TCP	629..889	CDD:239450
		PIPKc_PIKfyve	1829..2095	CDD:340437	86/359 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900