DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP5K59B and ppk-1

DIOPT Version :9

Sequence 1:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	NP_491576.2	Gene:	ppk-1 / 172184	WormBaseID:	WBGene00004087	Length:	611	Species:	Caenorhabditis elegans

Alignment Length:	590	Identity:	277/590 - (46%)
Similarity:	371/590 - (62%)	Gaps:	77/590 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DSSSASQAKLAEPSNASTDHVGNSSPDLGNRPNRASSKADKERKIGHRRVGEGGEITYKKIQTSQ 79
            |:....:|.:..|.|.:.|...|:   |||:.:|  .:.:.:.|:||||:.|.|.::|||:.|:.
Worm    28 DNGEKQEAPILRPDNEAKDLPLNT---LGNQTSR--EQQNTKEKLGHRRIDEQGGVSYKKVPTNA 87

  Fly    80 IMGSIQLGIQHTVGSLASKPKRDLLMMDFWEIESITFPPEGSSLTPAHHYSEFRYKIYAPIAFRY 144
            :|.:|||||.:::|||||.|.||:|:.||.:::.:.||..||::||:|.:.:||::.||||||||
Worm    88 LMQAIQLGISNSIGSLASLPNRDVLLQDFEKVDIVAFPAAGSTITPSHSFGDFRFRTYAPIAFRY 152

  Fly   145 FRDLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLLPGYYMN 209
            ||:||.|:|.||:.|:||.||:||||.||||||||::.||:||||||||||.:||||||||||||
Worm   153 FRNLFHIKPADFLRSICTEPLKELSNAGASGSIFYVSQDDQFIIKTVQHKEADFLQKLLPGYYMN 217

  Fly   210 LNQNPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANKAERAKKS 274
            |||||||||||||||:|.| |..|||||:|||||||.:|.||.|||:||||:||.||||||||..
Worm   218 LNQNPRTLLPKFFGLFCYQ-SLGKNIRLLVMNNLLPQTVTMHEKYDMKGSTYKRMANKAERAKPH 281

  Fly   275 PTYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQ 339
            ||.|||||:|.|.:|||::.....||:|:|.|||.|:|||||||||||:|:||:::.:||:..:.
Worm   282 PTLKDLDFLENHKDGIFIDPTALEALMKSISRDCLVMESFKIMDYSLLVGIHNVELGIKERAEQN 346

  Fly   340 RKPLRAPLAEDSDVDADDPLDGDAATGISRNKSVNRQRLVAHSTAMESIQAESEPIDDEEDVPPG 404
            |:...||..      :.|...|:.|    .|..|.:::.....|.             :.|||.|
Worm   347 RESHPAPST------SSDTFSGEKA----ENHKVLQEKFSVWDTG-------------DGDVPHG 388

  Fly   405 GIPARSEKGERLLLYIGIIDILQSYRLKKKLEHTFKSIIHDGETVSVCRPSFYAQRFQNFMAKTV 469
            |:|||:..|:||:||:|||||||:|||.||:|||:|:|:|||:|:||..|:|||.||..||.:.|
Worm   389 GVPARNSNGDRLVLYLGIIDILQNYRLLKKMEHTWKAILHDGDTISVHNPNFYASRFLTFMTEKV 453

  Fly   470 FRKIPSLDLPEIKGNHRKFRTLVTSYIALKHSPSKRKSLSKAIQRSIDSDNEVASRPVHASHSHS 534
            |:          ||.            |||.|||:|:.|.   ..|.:.|:.|.....|..|..|
Worm   454 FK----------KGT------------ALKQSPSRRRMLK---GNSHEDDSIVIVSSGHRQHRES 493

  Fly   535 SGKIHQPAKPPTTEPTPAGAAGGAERG-ATALGPAT-----------TSGASE------RAPPPV 581
                .:.....|...|. ||:....|| .|..|..|           ::|.:|      |.||..
Worm   494 ----ERDGLNMTVTVTD-GASTSTPRGDTTQFGSQTARESTRLYNRDSTGINEDRANSAREPPSS 553

  Fly   582 KQRTP 586
            ..|.|
Worm   554 MSRVP 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	224/394 (57%)
ppk-1	NP_491576.2	PIPKc_PIP5KI	86..456	CDD:340438	224/403 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159719
Domainoid	1	1.000	352	1.000	Domainoid score	I525
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H93492
Inparanoid	1	1.050	497	1.000	Inparanoid score	I761
Isobase	1	0.950	-	0	Normalized mean entropy	S1569
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	1	1.000	-	-		FOG0000462
OrthoInspector	1	1.000	-	-		otm14666
orthoMCL	1	0.900	-	-		OOG6_100438
Panther	1	1.100	-	-	LDO	PTHR23086
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2198
SonicParanoid	1	1.000	-	-		X284
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740