DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP5K59B and Pip4k2c

DIOPT Version :9

Sequence 1:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_038934240.1	Gene:	Pip4k2c / 140607	RGDID:	621711	Length:	434	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	135/485 - (27%)
Similarity:	226/485 - (46%)	Gaps:	87/485 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 MDSSSASQAKLAEPSNASTDHVGNSSPDLGNRPNRASSKADKERKIGHRRVGEGGEITYKKIQ-- 76
            |.|||...|  ..|:.|     |...|..|     .:||..|:            ....:|::
  Rat     1 MASSSVPPA--TAPAAA-----GGPGPGFG-----FASKTKKK------------HFVQQKVKVF 41

  Fly    77 --TSQIMGSIQLGIQHTVGSLASKPKRDLLMMDFWEIESITFPP--------EGSSLTPAHHY-- 129
              ...::|....|:.|::..|.:.|   |::....|:..:. ||        :.||....:::
  Rat    42 RAADPLVGVFLWGVAHSMELLMASP---LVLHQINELSQVP-PPVMLLPDDFKASSKIKVNNHLF 102

  Fly   130 ------SEFRYKIYAPIAFRYFRDLFGIQPDDFMMSMCTSPLRELSNPGASGSIFYLTTDDEFII 188
                  |.|::|.|.|..||..||.|.|...|:::|:..||..|  ..|:.|. |.::.|...:|
  Rat   103 HRENLPSHFKFKEYCPQVFRNLRDRFAIDDHDYLVSLTRSPPSE--TEGSDGR-FLISYDRTLVI 164

  Fly   189 KTVQHKEGEFLQKLLPGYYMNLNQ-NPRTLLPKFFGLYCLQTSNAKNIRLVVMNNLLPSSVKMHL 252
            |.|..::...:...|..|:..:.: :..||||:|.|:|.:...| ::..::||.|:....:.:|.
  Rat   165 KEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVEN-EDSYMLVMRNMFSHRLPVHR 228

  Fly   253 KYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQHPNGIFLEAETYAALIKTIQRDCTVLESFKIM 317
            |||||||...|:|:..|:.|:.||.||:||:.::.. :::..|.....::.::||...|...|||
  Rat   229 KYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQK-VYIGEEEKKVFLEKLKRDVEFLVQLKIM 292

  Fly   318 DYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGDAATGISRNKSVNRQRLV-AH 381
            |||||||:|::   ::..:.|:..|:|   .|:|:.|.|..|.|..|             || ::
  Rat   293 DYSLLLGIHDI---IRGSEPEEEGPVR---EEESEWDGDCNLTGPPA-------------LVGSY 338

  Fly   382 STAMESIQAESEPIDDEEDVPPGGIPA-------RSEKG--ERLLLYIGIIDILQSYRLKKKLEH 437
            .|:.|.|...   |.....:.||...:       ||.:|  ::.:.::|:||||..|..|||..|
  Rat   339 GTSPEGIGGY---IHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAH 400

  Fly   438 TFKSIIHD-GETVSVCRPSFYAQRFQNFMA 466
            ..|::.|. |..:|...|..||:||.:|::
  Rat   401 AAKTVKHGAGAEISTVHPEQYAKRFLDFIS 430

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	121/417 (29%)
Pip4k2c	XP_038934240.1	PIPKc	46..431	CDD:421701	121/416 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820