DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PIP5K59B and Pip4k2c

DIOPT Version :9

Sequence 1:	NP_001369113.1	Gene:	PIP5K59B / 37633	FlyBaseID:	FBgn0034789	Length:	891	Species:	Drosophila melanogaster
Sequence 2:	XP_011241590.1	Gene:	Pip4k2c / 117150	MGIID:	2152214	Length:	484	Species:	Mus musculus

Alignment Length:	481	Identity:	131/481 - (27%)
Similarity:	222/481 - (46%)	Gaps:	84/481 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 SASQAKLAEPSN-----ASTDHVGNSSPDLG--NRPNRASSKADKERKIGHRRVGEGGEITYKKI 75
            :|:|...|..|.     :|..|....:.|.|  .||:|..::.....:.|.|...:..|..::..
Mouse     2 TAAQVSTASGSGFGVAASSRFHSLGCAGDYGVLLRPSRHRTRGSWRPRPGIRLRLQNQEEAFRTA 66

  Fly    76 QTSQIMGSIQLGIQHTVG--SLASKP-----------KRDL-------LMMDFWEIESITFPP-- 118
            ::..:.|....|.:..||  ||...|           :||:       |:::  |:..:. ||
Mouse    67 ESEGVPGRGPAGGRVPVGRRSLGPAPGYRDWPGSGCSQRDIKGSGSEGLLIN--ELSQVP-PPVM 128

  Fly   119 -------EGSSLTPAHHY-------SEFRYKIYAPIAFRYFRDLFGIQPDDFMMSMCTSPLRELS 169
                   ..|.:...:|:       |.|::|.|.|..||..||.|.|...|:::|:..||..|
Mouse   129 LLPDDFKASSKIKVNNHFFHRENLPSHFKFKEYCPQVFRNLRDRFAIDDHDYLVSLTRSPPSE-- 191

  Fly   170 NPGASGSIFYLTTDDEFIIKTVQHKEGEFLQKLLPGYYMNLNQ-NPRTLLPKFFGLYCLQTSNAK 233
            ..|:.|. |.::.|...:||.|..::...:...|..|:..:.: :..||||:|.|:|.:...| :
Mouse   192 TEGSDGR-FLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVEN-E 254

  Fly   234 NIRLVVMNNLLPSSVKMHLKYDLKGSTFKRKANKAERAKKSPTYKDLDFMEQHPNGIFLEAETYA 298
            :..::||.|:....:.:|.|||||||...|:|:..|:.|:.||.||:||:.::.. :::..|...
Mouse   255 DSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQK-VYIGEEEKK 318

  Fly   299 ALIKTIQRDCTVLESFKIMDYSLLLGVHNLDVALKEKQSEQRKPLRAPLAEDSDVDADDPLDGDA 363
            ..::.::||...|...||||||||||:|::   ::..:.|:..|:|   .|:|:.|.|..|.|..
Mouse   319 VFLEKLKRDVEFLVQLKIMDYSLLLGIHDI---IRGSEPEEEGPVR---EEESEWDGDCNLAGPP 377

  Fly   364 ATGISRNKSVNRQRLV-AHSTAMESIQAESEPIDDEEDVPPGGIPA-------RSEKG--ERLLL 418
            |             || ::.|:.|.|...   |.....:.||...:       ||.:|  ::.:.
Mouse   378 A-------------LVGSYGTSPEGIGGY---IHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVY 426

  Fly   419 YIGIIDILQSYRLKKKLEHTFKSIIH 444
            ::|:||||..|..|||..|..|::.|
Mouse   427 FMGLIDILTQYDAKKKAAHAAKTVKH 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PIP5K59B	NP_001369113.1	PIPKc_PIP5KI	78..473	CDD:340438	117/414 (28%)
Pip4k2c	XP_011241590.1	PIPKc	117..349	CDD:391950	74/242 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5253
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1562683at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820