DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd59A and FOXH1

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_003914.1	Gene:	FOXH1 / 8928	HGNCID:	3814	Length:	365	Species:	Homo sapiens

Alignment Length:	286	Identity:	72/286 - (25%)
Similarity:	113/286 - (39%)	Gaps:	83/286 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 KPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKDKFPAWQNSIRHNLSLNDCFIKVPRE 149
            ||||:|:|:|.:.|..:|.::|.|:.|...:.:.||::::.:..|::|||||||.|.||.|||::
Human    33 KPPYTYLAMIALVIQAAPSRRLKLAQIIRQVQAVFPFFREDYEGWKDSIRHNLSSNRCFRKVPKD 97

  Fly   150 PGNP-GKGNFWTLD---------------------------PLAEDMFDNGSFLRRRKRYK---- 182
            |..| .|||||.:|                           ..|:|:   |.::...:.|:
Human    98 PAKPQAKGNFWAVDVSLIPAEALRLQNTALCRRWQNGGARGAFAKDL---GPYVLHGRPYRPPSP 159

  Fly   183 RAPTMQRFSFPAVFGTLSPFWIRKPVP-LVPVHFNVPNFNGSREFDVVHNPADVFDSALRADKKF 246
            ..|..:.||..::.|....   ..|.| |.|....||...|:...:.|..|.
Human   160 PPPPSEGFSIKSLLGGSGE---GAPWPGLAPQSSPVPAGTGNSGEEAVPTPP------------- 208

  Fly   247 NFFANAEASFYQGSQSGDKFDRLPFMNRGRGADVLDALPHSSGSGGGVGGGSESSRGSKYKSPYA 311
              ..::|...:       ....||...|..|..|         .||.:|..:.|      ..|.|
Human   209 --LPSSERPLW-------PLCPLPGPTRVEGETV---------QGGAIGPSTLS------PEPRA 249

  Fly   312 FDVATVASAAGIPGHRDYAERLSAGG 337
            :.:..:...| :||.|      |:||
Human   250 WPLHLLQGTA-VPGGR------SSGG 268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	38/113 (34%)
FOXH1	NP_003914.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		FH	33..111	CDD:238016	35/77 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..215		15/81 (19%)
		SMAD-interaction domain (SID)	273..354
		Fast/FoxH1 motif 1 (FM1)	277..281
		Fast/FoxH1 motif 2 (FM2)	287..293
		SMAD interaction motif (SIM)	327..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820