DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fd59A and Foxm1

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_113821.2	Gene:	Foxm1 / 58921	RGDID:	61807	Length:	771	Species:	Rattus norvegicus

Alignment Length:	299	Identity:	79/299 - (26%)
Similarity:	110/299 - (36%)	Gaps:	104/299 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TSTDPMHTLHDSVSLSP-------PLIK----------SSRGGSSIG------------------ 32
            ||||...|...:.:|.|       |:.|          .|.||.:.|
  Rat   127 TSTDSKRTELITETLGPKPGAKGVPVPKPPGALPRQRQESCGGEAAGCTLDNSLTNIQWLGKMSS 191

  Fly    33 NGIG-CSASSRTAAADAMSMGCDDSDIEPSSMGGSGAAGGNGDGSGSSGGPLVKPPYSYIALITM 96
            :|:| ||........:...:..:...:|..|     .|..:...|.|.     :|||||:|:|..
  Rat   192 DGLGRCSIKQELEEKENCHLEQNRVKVEAPS-----RASVSWQDSVSE-----RPPYSYMAMIQF 246

  Fly    97 AILQSPHKKLTLSGICDFIMSRFPYYKD-KFPAW------------QNSIRHNLSLNDCFIKVPR 148
            ||..:..|::||..|..:|...|||:|. ..|.|            ||||||||||:|.|:   |
  Rat   247 AINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKCWHQAYHKLGPQNSIRHNLSLHDMFV---R 308

  Fly   149 EPGNPGKGNFWTLDPLA------EDMF---DNGS----------------FLRRR---------- 178
            |....||.:|||:.|.|      :.:|   :.||                .|||.
  Rat   309 ETSANGKVSFWTIHPSANRYLTLDQVFKPLEPGSPQSPEHLESQQKRPNPELRRNVTIKTELPLG 373

  Fly   179 KRYKRAPTMQRFS-------FPAVFGTLSPFWIRKPVPL 210
            .|.|..|.:.|.|       ||.....:....::.|:||
  Rat   374 ARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPL 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	42/107 (39%)
Foxm1	NP_113821.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..54
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..165		9/37 (24%)
		FH	235..322	CDD:238016	39/89 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..361		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	542..568
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..655
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	693..718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820