DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd59A and foxa2

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_989423.1	Gene:	foxa2 / 395063	XenbaseID:	XB-GENE-480476	Length:	434	Species:	Xenopus tropicalis

Alignment Length:	229	Identity:	84/229 - (36%)
Similarity:	112/229 - (48%)	Gaps:	69/229 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SSIGN--------------GIGCSASSRTAAADAMSMGCDDSDIEPSSMG---GSGAAGGNGDGS 76
            ||:||              .:...::|....|.:|:|...::.:.||..|   |:||..|.|.|.
Frog    26 SSVGNMNAGLSMNPMNTYMSMSAMSTSANMTAGSMNMSYVNTGMSPSLTGMSPGTGAMTGMGTGV 90

  Fly    77 GSSGGPL--------------------------------------------------VKPPYSYI 91
            .|....|                                                  .|||||||
Frog    91 ASMASHLSPSMSPMSAQATSMNALAPYTNMNSMSPIYGQSNINRSRDPKTYRRSYTHAKPPYSYI 155

  Fly    92 ALITMAILQSPHKKLTLSGICDFIMSRFPYYKDKFPAWQNSIRHNLSLNDCFIKVPREPGNPGKG 156
            :||||||.|||:|.||||.|..:||..||:|:.....|||||||:||.||||:||||.|..||||
Frog   156 SLITMAIQQSPNKMLTLSEIYQWIMDLFPFYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKG 220

  Fly   157 NFWTLDPLAEDMFDNGSFLRRRKRYK--RAPTMQ 188
            :||||.|.:.:||:||.:|||:||:|  :.|:::
Frog   221 SFWTLHPDSGNMFENGCYLRRQKRFKCEKKPSLR 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	56/85 (66%)
foxa2	NP_989423.1	Forkhead_N	17..148	CDD:369872	19/121 (16%)
		FH	149..237	CDD:214627	57/87 (66%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..339		1/6 (17%)
		HNF_C	349..423	CDD:370449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910