DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd59A and foxk2a

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_001184186.1	Gene:	foxk2a / 324141	ZFINID:	ZDB-GENE-030131-2861	Length:	544	Species:	Danio rerio

Alignment Length:	497	Identity:	134/497 - (26%)
Similarity:	184/497 - (37%)	Gaps:	126/497 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TSTDPMHTLHDSVSLSPPLIKSSRGGSSIGNGIGCSASSRTAAADAMSMG----------CDDSD 57
            |.:.|.:..|    |..|| .|..|..|..|  .|.:|.|.|...:..||          ...|:
Zfish   131 TISIPENITH----LRSPL-PSPTGTISAAN--SCPSSPRGAGLSSYRMGRGLTAELINENSQSE 188

  Fly    58 IEPSSMGGSGAAGGNGDGSGSSGGPLVKPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYY 122
            |:..:.||....    |.|        ||||||..||..||..:|.|:|||:||...|...:|||
Zfish   189 IDKEASGGDSPK----DDS--------KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYY 241

  Fly   123 KDKFPAWQNSIRHNLSLNDCFIKVPREPGNPGKGNFWTLDPLAEDMFDNGSFLRRRKRYKRAPTM 187
            :.....||||||||||||..||||.|....||||:||.:||.:|....:.:|.:||.|
Zfish   242 RTADKGWQNSIRHNLSLNRYFIKVARSQEEPGKGSFWRIDPSSEGKLMDQAFRKRRPR------- 299

  Fly   188 QRFSFPAVFGTLSPFWIRKPVPLVPVHFNVPNF--------NGSREFDVVHNPADVFDSALRADK 244
               ..|.....|.|...|. .|..|.|..|.:.        :.|||...:  |.:...||..|.:
Zfish   300 ---GVPCFRTPLGPLSSRS-APASPTHTGVLSAHSSGVQTPDSSREGSPL--PLEPEPSAAAAPQ 358

  Fly   245 KFNFFANAEASFYQGSQSGDKFDRLPFMNRGRGADVLDALPHSSGSGGGVGGGSESSRGSKYKSP 309
            . ......|:.|.|.:.               |:.||.|:....               .:...|
Zfish   359 P-KLAVIQESCFTQNTP---------------GSPVLIAVQQPL---------------QQSLKP 392

  Fly   310 YAFDVATVASAAG-------------IPGHRDY-AERLSAGGGYMDLNVYNDDADTEADAEAEGD 360
            .:|.|||.||:|.             ||....: ||:.:.....:.:.|    ....|.|.|.|.
Zfish   393 VSFSVATPASSAAPQPVMQTLHLLHQIPAACVFRAEQQNGDAQEVKVTV----EPVPAVAAAPGA 453

  Fly   361 DDSCEDKIDVESGNE---------QEDSHISDSV--DSACTNRLDAPPEALIFEASAEASDSSPR 414
            .......:.|....:         |..:|::.:.  .||.|   .:|...|...|||.|  |.|.
Zfish   454 SSRVLQPLAVAPRGQHQLPVKPITQNGTHVAAAAIQGSAST---ASPLHMLATHASASA--SLPT 513

  Fly   415 RRFDSEPLVLRTSKQSSAKDFRIETLIGHHLHRGGSQEETSD 456
            :|.:.|.:....||:...:|           ...|.|::.:|
Zfish   514 KRQNGEQVEQPDSKRLKMED-----------GDAGQQQDHTD 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	47/85 (55%)
foxk2a	NP_001184186.1	FHA	16..105	CDD:238017
foxk2a	NP_001184186.1	Forkhead	204..290	CDD:278670	47/85 (55%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850