DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd59A and Foxk2

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	XP_006247952.1	Gene:	Foxk2 / 303753	RGDID:	1305408	Length:	650	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	130/497 - (26%)
Similarity:	175/497 - (35%)	Gaps:	140/497 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSPPLIKSSRGGSSIGNGIGCSASSRTAAADAMSMG----------CDDSDIEPSSMGGSGAAGG 71
            :||  :.|..|..|..|  .|.:|.|.|.:....||          .|:|..|    ....|:||
  Rat   185 ISP--LPSPTGTISAAN--SCPSSPRGAGSSGYKMGRVIPSDLNLMADNSQPE----NEKEASGG 241

  Fly    72 NGDGSGSSGGPLVKPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKDKFPAWQNSIRHN 136
            :.....|      ||||||..||..||..:|.|:|||:||...|...:|||:.....||||||||
  Rat   242 DSPKDDS------KPPYSYAQLIVQAITMAPDKQLTLNGIYTHITKNYPYYRTADKGWQNSIRHN 300

  Fly   137 LSLNDCFIKVPREPGNPGKGNFWTLDPLAEDMFDNGSFLRRRKRYKRAPTMQRFSFPAVFGTLSP 201
            ||||..||||||....||||:||.:||.:|......:|.:||.|          ..|.....|.|
  Rat   301 LSLNRYFIKVPRSQEEPGKGSFWRIDPASESKLVEQAFRKRRPR----------GVPCFRTPLGP 355

  Fly   202 FWIRKPVPLVPVHFNVPNFNG---------SREFDVVHNPADVFDSALRADKKFNFFANAEASFY 257
            ...|. .|..|.|..|.:.:.         |||    .:||.:......:..|....  .||.|.
  Rat   356 LSSRS-APASPNHAGVLSAHSSGAQTPESLSRE----GSPAPLEPEPGASQPKLAVI--QEARFA 413

  Fly   258 QGSQSGDKFDRLPFMNRGRGADVLDALPHSSGSGGGVGGGSESSRGSKYKSPYAFDVAT-VASAA 321
            | |..|......|.:     ..|...||.:.                   .|..:.||| |.:..
  Rat   414 Q-SAPGSPLSSQPVL-----ITVQRQLPPAI-------------------KPVTYTVATPVTTPT 453

  Fly   322 GIPG--------HRDYAERLSAGGGYMDLNVY---NDDADTEA-----DAEAEGDDDSCEDKIDV 370
            ..|.        |:..|..:::..|....|.|   .....|:|     ..|.:.:.|..|.::.|
  Rat   454 SQPPVVQTVHVVHQIPAVAVTSVAGLAPANTYTVAGQAVVTQAAVLAPKTEPQENGDHREVRVKV 518

  Fly   371 E--------------------SGN-----------------------EQEDSHI---SDSVDSAC 389
            |                    .|.                       .|..:|:   ..:|.|..
  Rat   519 EPVPAISPATLGAASRIIQTSQGTPVQTVTIVQQAPLGQHQLPIKTVTQNGTHVVPMPTAVHSQV 583

  Fly   390 TNRLDAPPEALIFEASAEASDSSPRRRFD--SEPLVLRTSKQ 429
            .|.:.:|...|...|||.||..:.|:..|  .:|.:.|...:
  Rat   584 NNAVASPLHMLATHASASASLPTKRQNGDQAEQPELKRVKAE 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	48/85 (56%)
Foxk2	XP_006247952.1	FHA	41..145	CDD:238017
Foxk2	XP_006247952.1	Forkhead	249..335	CDD:278670	48/85 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820