DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd59A and fhl1

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_594272.1	Gene:	fhl1 / 2541552	PomBaseID:	SPAC1142.08	Length:	743	Species:	Schizosaccharomyces pombe

Alignment Length:	204	Identity:	71/204 - (34%)
Similarity:	98/204 - (48%)	Gaps:	35/204 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 HTSTDPMHTL--------HDSVS------LSP-PLIKSSRGGSSIGNGIGCSASSRTAAADAMSM 51
            |......|||        |.:||      ||| |.::.:.....|......||.......:.:..
pombe   200 HPDAANAHTLASLNQPPKHLTVSPSSIQRLSPQPYVRPTSDERPIETDSSVSAPKVANHDEELKQ 264

  Fly    52 G----CDDSDIEPSSMGGSGAAGGNGDGSGSSGGPLVKPPYSYIALITMAILQSPHKKLTLSGIC 112
            |    ..|:.:.|..           :||..:|....||..||..||...::.:|:||:||..||
pombe   265 GKSTSPSDTVLHPDL-----------NGSPDTGDATQKPNLSYANLIARTLIANPNKKMTLGDIC 318

  Fly   113 DFIMSRFPYYKDKFPAWQNSIRHNLSLNDCFIKVPREPGNPGKGNFWTLDPLAEDMFDNGSFLRR 177
            ::|.:.:.||:.:.|||.||||||||||..||::||....||||:||.|||...|.|: |:|.||
pombe   319 EWIANNWSYYRHQPPAWHNSIRHNLSLNKAFIRIPRRQNEPGKGSFWMLDPSYIDQFE-GNFFRR 382

  Fly   178 RKRYKRAPT 186
            .|:    ||
pombe   383 TKK----PT 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	44/85 (52%)
fhl1	NP_594272.1	COG5025	1..564	CDD:227358	71/204 (35%)
		FHA	<38..119	CDD:238017
		Forkhead	291..376	CDD:278670	43/84 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	101	1.000	Domainoid score	I1793
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		otm47190
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.840