DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd59A and Foxg1

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_036692.1	Gene:	Foxg1 / 24370	RGDID:	2619	Length:	480	Species:	Rattus norvegicus

Alignment Length:	328	Identity:	108/328 - (32%)
Similarity:	146/328 - (44%)	Gaps:	67/328 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSPPLIKSSRGGSSIGNGIGCSASSRTAAADAMSMGCDDSDIEPSSMGG---SGAAGGNGDGSG- 77
            |.||   |:....:..:.:|.........|:...:|.|:.: :.:..||   .||..|..||.|
  Rat   100 LLPP---SAALDGAKADALGAKGEPGGGPAELAPVGPDEKE-KGAGAGGEEKKGAGEGGKDGEGG 160

  Fly    78 ----SSGGPLVKPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKDKFPAWQNSIRHNLS 138
                ...|...|||:||.|||.|||.|||.|:|||:||.:|||..||||::....||||||||||
  Rat   161 KEGDKKNGKYEKPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYRENKQGWQNSIRHNLS 225

  Fly   139 LNDCFIKVPREPGNPGKGNFWTLDPLAEDMFDNGSF--LRRRKRYKRAP---------TMQRFSF 192
            ||.||:||||...:|||||:|.|||.::|:|..|:.  ||||....||.         |....:|
  Rat   226 LNKCFVKVPRHYDDPGKGNYWMLDPSSDDVFIGGTTGKLRRRSTTSRAKLAFKRGARLTSTGLTF 290

  Fly   193 PAVFGTLSPFWIRKPVPLVPVHFNVPNFNGSREFDVVHNPADVFDSALRADKKFNFFANAEASFY 257
            ....|:|  :|     |:.|             |..:|:|        ||....:         |
  Rat   291 MDRAGSL--YW-----PMSP-------------FLSLHHP--------RASSTLS---------Y 318

  Fly   258 QGSQSGDKFDRLPFMNRGRGADVLDALPHSSGSGGGVGGGSESSRGSKYKSPYAFDVATVAS-AA 321
            .|:.|......:|:      :.||......:........|....|....:.|||....|.|: ||
  Rat   319 NGTTSAYPSHPMPY------SSVLTQNSLGNNHSFSTANGLSVDRLVNGEIPYATHHLTAAALAA 377

  Fly   322 GIP 324
            .:|
  Rat   378 SVP 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	56/85 (66%)
Foxg1	NP_036692.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	31..172		17/75 (23%)
		FH_FOXG	172..250	CDD:410795	52/77 (68%)
		COG5025	<175..>347	CDD:227358	78/214 (36%)
		Required for interaction with TLE6. /evidence=ECO:0000250\|UniProtKB:Q60987	240..335		34/137 (25%)
		Interaction with KDM5B. /evidence=ECO:0000250	374..397		3/7 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..446
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820