Protein Alignment fd59A and FOXO1

DIOPT Version :10

• Sequence 1: NP_523814.1
• Gene: fd59A / 37631
• FlyBaseID: FBgn0004896
• Length: 456
• Species: Drosophila melanogaster
• Sequence 2: NP_002006.2
• Gene: FOXO1 / 2308
• HGNCID: 3819
• Length: 655
• Species: Homo sapiens
• Alignment Length: 277
• Identity: 77/277 - (27%)
• Similarity: 108/277 - (38%)
• Gaps: 86/277 - (31%)

  Fly     7 PMHTLHDSVSLSPPLIKSSRGGSSIGNGIGCSASSRTAAADAMS--MGCDDSDIEPSSMGGSGAA 69
            |..:..:|.:.||....|:........|:. |||:...:||.||  ...::|:..|.:.|...||
Human    30 PEFSQSNSATSSPAPSGSAAANPDAAAGLP-SASAAAVSADFMSNLSLLEESEDFPQAPGSVAAA 93

  Fly    70 ----------GG-NGDGSG---------------------------SSGGPLVKPP--------- 87
                      || .||..|                           ::.|||...|
Human    94 VAAAAAAAATGGLCGDFQGPEAGCLHPAPPQPPPPGPLSQHPPVPPAAAGPLAGQPRKSSSSRRN 158

  Fly    88 ----YSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKDK-----FPAWQNSIRHNLSLNDCF 143
                .||..|||.||..|..|:||||.|.::::...||:|||     ...|:|||||||||:..|
Human   159 AWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVPYFKDKGDSNSSAGWKNSIRHNLSLHSKF 223

  Fly   144 IKVPREPGNPGKGNFWTLDP-----------LAEDMFDNGSFLRRRKRYKR-------------- 183
            |:|..|  ..||.::|.|:|           .|..|.:|..|.:.|.|..:
Human   224 IRVQNE--GTGKSSWWMLNPEGGKSGKSPRRRAASMDNNSKFAKSRSRAAKKKASLQSGQEGAGD 286

  Fly   184 APTMQRFSFPAVFGTLS 200
            :|..|...:||..|:.|
Human   287 SPGSQFSKWPASPGSHS 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	FH_FOXD4-like	85..180	CDD:410822	44/123 (36%)
FOXO1	NP_002006.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..63		8/33 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..158		4/41 (10%)
		FH_FOXO1	151..249	CDD:410834	38/99 (38%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	211..218		6/6 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	234..344		15/70 (21%)
		DNA-binding. /evidence=ECO:0000269|PubMed:18786403	234..237		0/2 (0%)
		Nuclear localization signal	251..253		0/1 (0%)
		Sufficient for interaction with NLK. /evidence=ECO:0000250|UniProtKB:Q9R1E0	283..563		6/21 (29%)
		Required for interaction with RUNX2. /evidence=ECO:0000250|UniProtKB:Q9R1E0	363..459
		FOXO_KIX_bdg	423..504	CDD:465228
		Required for interaction with SIRT1. /evidence=ECO:0000250|UniProtKB:Q9R1E0	462..466
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	507..537
		FOXO-TAD	597..633	CDD:435506