DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd59A and FOXM1

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_973731.1	Gene:	FOXM1 / 2305	HGNCID:	3818	Length:	801	Species:	Homo sapiens

Alignment Length:	169	Identity:	57/169 - (33%)
Similarity:	77/169 - (45%)	Gaps:	46/169 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 KPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKD-KFPAWQNSIRHNLSLNDCFIKVPR 148
            :|||||:|:|..||..:..|::||..|..:|...|||:|. ..|.|:|||||||||:|.|:   |
Human   236 RPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFV---R 297

  Fly   149 EPGNPGKGNFWTLDPLA------EDMF---DNGS----------------FLRRR---------- 178
            |....||.:|||:.|.|      :.:|   |.||                .|||.
Human   298 ETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTIKTELPLG 362

  Fly   179 KRYKRAPTMQRFS-------FPAVFGTLSPFWIRKPVPL 210
            .|.|..|.:.|.|       ||.....:....::.|:||
Human   363 ARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPL 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	41/95 (43%)
FOXM1	NP_973731.1	FH	236..311	CDD:238016	38/77 (49%)
FOXM1	NP_973731.1	Herpes_ICP4_C	504..>749	CDD:332854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820