DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fd59A and FOXE1

DIOPT Version :9

Sequence 1:NP_523814.1 Gene:fd59A / 37631 FlyBaseID:FBgn0004896 Length:456 Species:Drosophila melanogaster
Sequence 2:NP_004464.2 Gene:FOXE1 / 2304 HGNCID:3806 Length:373 Species:Homo sapiens


Alignment Length:407 Identity:125/407 - (30%)
Similarity:157/407 - (38%) Gaps:148/407 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 PP------LIKSSRGGSSIGNGIGCSASSRTAAADAMSMGCDDSDIEPSSMGGSGAAGGNGDGSG 77
            ||      .:|..||.::.|.|:                              .|.|.|.|.|..
Human     9 PPQPEVLATVKEERGETAAGAGV------------------------------PGEATGRGAGGR 43

  Fly    78 SSGGPLV--KPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKDKFPAWQNSIRHNLSLN 140
            ....||.  ||||||||||.|||..:|.::|||.||..||..|||:|:|....|||||||||:||
Human    44 RRKRPLQRGKPPYSYIALIAMAIAHAPERRLTLGGIYKFITERFPFYRDNPKKWQNSIRHNLTLN 108

  Fly   141 DCFIKVPREPGNPGKGNFWTLDPLAEDMFDNGSFLRRRKRYKR---------------------- 183
            |||:|:|||.|.|||||:|.|||.|||||::|||||||||:||                      
Human   109 DCFLKIPREAGRPGKGNYWALDPNAEDMFESGSFLRRRKRFKRSDLSTYPAYMHDAAAAAAAAAA 173

  Fly   184 ----------APTMQRFSFP-AVFGTLSPFWIRKPVP---------------LVPVHFNVPNF-- 220
                      |....|..:| ||:...:|..:..|.|               |||.....|..  
Human   174 AAAAAAIFPGAVPAARPPYPGAVYAGYAPPSLAAPPPVYYPAASPGPCRVFGLVPERPLSPELGP 238

  Fly   221 -----NGSREFDVVHNPADVF--------------DSALRADKKFNFFANAEASFYQGSQSGDKF 266
                 .||..|.....||...              .||..|     .:|..:.::.||:.|.   
Human   239 APSGPGGSCAFASAGAPATTTGYQPAGCTGARPANPSAYAA-----AYAGPDGAYPQGAGSA--- 295

  Fly   267 DRLPFMNRGRGADVLDALPHSSGSGGGV----------------------------GGGSESSRG 303
               .|...||.|.  .|.|.:.||.|||                            ||.|..:..
Human   296 ---IFAAAGRLAG--PASPPAGGSSGGVETTVDFYGRTSPGQFGALGACYNPGGQLGGASAGAYH 355

  Fly   304 SKYKSPYAFDVATVASA 320
            :::.:.|...:....||
Human   356 ARHAAAYPGGIDRFVSA 372

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fd59ANP_523814.1 Forkhead 85..171 CDD:278670 59/85 (69%)
FOXE1NP_004464.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 19..51 12/61 (20%)
FH 53..141 CDD:214627 59/87 (68%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG2294
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1270467at2759
OrthoFinder 1 1.000 - - FOG0000010
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11829
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

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