DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd59A and FOXJ1

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_001445.2	Gene:	FOXJ1 / 2302	HGNCID:	3816	Length:	421	Species:	Homo sapiens

Alignment Length:	422	Identity:	119/422 - (28%)
Similarity:	151/422 - (35%)	Gaps:	125/422 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GCSASSRTAAADAMSMGCDDSDIEPSSMGGS-----GAAGGNGDGSGSSGGPLVKPPYSYIALIT 95
            |.:|.....|||...:|...:..:|:|...|     |......|....:..|.|||||||..||.
Human    67 GSAAPGSPLAADPACLGQPHTPGKPTSSCTSRSAPPGLQAPPPDDVDYATNPHVKPPYSYATLIC 131

  Fly    96 MAILQSPHKKLTLSGICDFIMSRFPYYKDKFPAWQNSIRHNLSLNDCFIKVPREPGNPGKGNFWT 160
            ||:..|...|:|||.|..:|...|.|::...|.||||||||||||.||||||||...||||.||.
Human   132 MAMQASKATKITLSAIYKWITDNFCYFRHADPTWQNSIRHNLSLNKCFIKVPREKDEPGKGGFWR 196

  Fly   161 LDPLAEDMFDNGSFLRRRKRYKRAPTMQRFSFPAVFGTLSPFWIRKPVPLVPVHFNVPNFNGSRE 225
            :||...:...:|:|.:||                               |.|||
Human   197 IDPQYAERLLSGAFKKRR-------------------------------LPPVH----------- 219

  Fly   226 FDVVHNPADVFDSALRADKKFNFFANAEASFYQGSQSGDKFDRL-PFMNRGRGADVLDALPHSSG 289
               :| ||               ||.      |.:|......|. |.........:|.....::|
Human   220 ---IH-PA---------------FAR------QAAQEPSAVPRAGPLTVNTEAQQLLREFEEATG 259

  Fly   290 SGGGVGGGSESSRGSKYKSPYAFDVATV--------------ASAAGIPGHRDYAERLSAG--GG 338
            ..|  .|..|...|.|.|.|....||.|              .....:.|:.|:.....||  ||
Human   260 EAG--WGAGEGRLGHKRKQPLPKRVAKVPRPPSTLLPTPEEQGELEPLKGNFDWEAIFDAGTLGG 322

  Fly   339 YM--------------------DLNVYNDDADTEA--DAEAEGDDDSCE-DKIDVESGNEQEDSH 380
            .:                    ||.::....|..|  ....|...||.: |:..:.:...|   |
Human   323 ELGALEALELSPPLSPASHVDVDLTIHGRHIDCPATWGPSVEQAADSLDFDETFLATSFLQ---H 384

  Fly   381 ISDSVDSACTNRLDAPPEALIFEA--SAEASD 410
            ..|...|.|     .|||.| |||  :..|||
Human   385 PWDESGSGC-----LPPEPL-FEAGDATLASD 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	48/85 (56%)
FOXJ1	NP_001445.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..34
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	48..116		11/48 (23%)
		Forkhead	121..205	CDD:306709	48/83 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..302		10/42 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850