DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fd59A and FOXF2

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_001443.1	Gene:	FOXF2 / 2295	HGNCID:	3810	Length:	444	Species:	Homo sapiens

Alignment Length:	358	Identity:	115/358 - (32%)
Similarity:	159/358 - (44%)	Gaps:	97/358 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSPP--------LIKSSRGGSSIGNGIGC-SASSRTAAADAMSMGCDDSDIEPSSMGGSGAAGGN 72
            :|||        ....:...||..:...| |:||.:.:|.|.|..|       .|.||.||..|:
Human    28 MSPPPAAAAAAAAAPETTSSSSSSSSASCASSSSSSNSASAPSAAC-------KSAGGGGAGAGS 85

  Fly    73 GDGSGSSGG---PLVKPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFPYYKDKFPAWQNSIR 134
            |....:|.|   | .||||||||||.|||..||.|:||||.|..|:.:|||:::..:..|:||:|
Human    86 GGAKKASSGLRRP-EKPPYSYIALIVMAIQSSPSKRLTLSEIYQFLQARFPFFRGAYQGWKNSVR 149

  Fly   135 HNLSLNDCFIKVPREPGNPGKGNFWTLDPLAEDMFDNGSFLRRRKRYKRAPTMQRFSFPAVFGTL 199
            ||||||:||||:|:..|.||||::||:||.:|.||:.|||.||.:.::
Human   150 HNLSLNECFIKLPKGLGRPGKGHYWTIDPASEFMFEEGSFRRRPRGFR----------------- 197

  Fly   200 SPFWIRKPVPLVPVHFNVPNFNGSREFDVVHNPADVFDSALRADKKFNFFANAEASFYQGSQSG- 263
                 ||...|.|::..|.:..|             |.::| ..:.|:|.|...|.....||.|
Human   198 -----RKCQALKPMYHRVVSGLG-------------FGASL-LPQGFDFQAPPSAPLGCHSQGGY 243

  Fly   264 ------------------------DKFDRLPFMNRGRGADVLDALPHSSG------SGGGVGG-- 296
                                    .....:|.|:...|:..:.:.|..:|      :|||.||
Human   244 GGLDMMPAGYDAGAGAPSHAHPHHHHHHHVPHMSPNPGSTYMASCPVPAGPGGVGAAGGGGGGDY 308

  Fly   297 GSESSRGSKYKSPYAFDVATVASAAGIPGHRDY 329
            |.:||......||        |.|:.|..|..|
Human   309 GPDSSSSPVPSSP--------AMASAIECHSPY 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	52/85 (61%)
FOXF2	NP_001443.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..98		19/72 (26%)
		FH	100..188	CDD:214627	52/87 (60%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	256..323		15/74 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..367
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000