DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fd59A and unc-130

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_496411.1	Gene:	unc-130 / 174721	WormBaseID:	WBGene00006853	Length:	333	Species:	Caenorhabditis elegans

Alignment Length:	229	Identity:	103/229 - (44%)
Similarity:	128/229 - (55%)	Gaps:	31/229 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SRTAAADAMSMGCDDSDIEPSSMGGSGAAGGNGDGSGSSGGPLVKPPYSYIALITMAILQSPHKK 105
            |.::|||:.|....|.|.:..|......       ||.......||||||||||.|:||.||.||
Worm    90 STSSAADSSSDDAKDDDDDDDSTSRKSM-------SGHRKSSHAKPPYSYIALIAMSILNSPEKK 147

  Fly   106 LTLSGICDFIMSRFPYYKDKFPAWQNSIRHNLSLNDCFIKVPREPGNPGKGNFWTLDPLAEDMFD 170
            ||||.||:||:::|.|||:|||||||||||||||||||:||.|.||||||||:|.|||..|||||
Worm   148 LTLSEICEFIINKFEYYKEKFPAWQNSIRHNLSLNDCFVKVARGPGNPGKGNYWALDPNCEDMFD 212

  Fly   171 NGSFLRRRKRYKR-APTMQR------FSFPAVFGTLSPFWIR-----------------KPVPLV 211
            ||||||||||||: :.|...      ..||.......||..|                 :.||.:
Worm   213 NGSFLRRRKRYKKNSDTYHEMMSHHPMPFPPFLPQGMPFPPRMMHPMANIPMLGHPMNPRAVPNM 277

  Fly   212 PVHFNVPNFNGSREFDVVHNPADVFDSALRADKK 245
            |..|...|.:..:...::.:.....|:.:.:.:|
Worm   278 PAFFIPQNIDSQKLLSMMASRIMPMDAPVSSGQK 311

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	67/85 (79%)
unc-130	NP_496411.1	COG5025	<126..330	CDD:227358	93/186 (50%)
unc-130	NP_496411.1	Forkhead	127..212	CDD:365978	66/84 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I2679
eggNOG	1	0.900	-	-		E2759_KOG2294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1393
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1270467at2759
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	1	1.000	-	-		oto20500
orthoMCL	1	0.900	-	-		OOG6_108564
Panther	1	1.100	-	-	LDO	PTHR11829
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2114
SonicParanoid	1	1.000	-	-		X1212
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.760