DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fd59A and Foxa2

DIOPT Version :9

Sequence 1:	NP_523814.1	Gene:	fd59A / 37631	FlyBaseID:	FBgn0004896	Length:	456	Species:	Drosophila melanogaster
Sequence 2:	NP_001277994.1	Gene:	Foxa2 / 15376	MGIID:	1347476	Length:	465	Species:	Mus musculus

Alignment Length:	192	Identity:	86/192 - (44%)
Similarity:	107/192 - (55%)	Gaps:	34/192 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LSPPLIKSSRGGSSIGNGIGCSASSRTAAADAMSMGCDDSDIEP--SSMGG--SGAAGGNGD-GS 76
            :||.|     .|.|.|.|.....|....||....||   ..:.|  |.:||  :||.||... .:
Mouse    79 MSPSL-----AGMSPGAGAMAGMSGSAGAAGVAGMG---PHLSPSLSPLGGQAAGAMGGLAPYAN 135

  Fly    77 GSSGGPL---------------------VKPPYSYIALITMAILQSPHKKLTLSGICDFIMSRFP 120
            .:|..|:                     .|||||||:||||||.|||:|.||||.|..:||..||
Mouse   136 MNSMSPMYGQAGLSRARDPKTYRRSYTHAKPPYSYISLITMAIQQSPNKMLTLSEIYQWIMDLFP 200

  Fly   121 YYKDKFPAWQNSIRHNLSLNDCFIKVPREPGNPGKGNFWTLDPLAEDMFDNGSFLRRRKRYK 182
            :|:.....|||||||:||.||||:||||.|..||||:||||.|.:.:||:||.:|||:||:|
Mouse   201 FYRQNQQRWQNSIRHSLSFNDCFLKVPRSPDKPGKGSFWTLHPDSGNMFENGCYLRRQKRFK 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fd59A	NP_523814.1	Forkhead	85..171	CDD:278670	56/85 (66%)
Foxa2	NP_001277994.1	Forkhead_N	23..164	CDD:254796	22/92 (24%)
		FH	165..253	CDD:214627	57/87 (66%)
		DUF4799	<224..319	CDD:292674	24/39 (62%)
		HNF_C	381..454	CDD:286443
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000010
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910