DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and SLC9A3R1

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_004243.1	Gene:	SLC9A3R1 / 9368	HGNCID:	11075	Length:	358	Species:	Homo sapiens

Alignment Length:	480	Identity:	91/480 - (18%)
Similarity:	155/480 - (32%)	Gaps:	154/480 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 PFPELIHMVTLDKTGKKSFGICIVRGEVKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSL 86
            |.|.|   ..|:| |...:|..: .||      ....|.:|:.:.|.|||...| |..|||::.:
Human    10 PLPRL---CCLEK-GPNGYGFHL-HGE------KGKLGQYIRLVEPGSPAEKAG-LLAGDRLVEV 62

  Fly    87 NGKDVRNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSNGYMQAKNKFNQEQTTNNNA 151
            ||::|...|.|.|:..|:.|...:.|.:            .||.::..:|......:|:......
Human    63 NGENVEKETHQQVVSRIRAALNAVRLLV------------VDPETDEQLQKLGVQVREELLRAQE 115

  Fly   152 SGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYE 216
            :.||.......:.||....|..:.                   ||:...:.|::..|:
Human   116 APGQAEPPAAAEVQGAGNENEPRE-------------------ADKSHPEQRELRPRL------- 154

  Fly   217 IDRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMKDLRRIEVQRDASKPLGLALAGHKD 281
                    |.:.|                                        .|.|.....|.|
Human   155 --------CTMKK----------------------------------------GPSGYGFNLHSD 171

  Fly   282 RQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMITSRRKP 346
            :.|...|:..|||:....:..::..|.||||||..::.:.|           ||.:..|.:
Human   172 KSKPGQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEGKQH-----------GDVVSAIRA---- 221

  Fly   347 NDEGMCVKPIKKFPTASDETKFIF-----DQFPKARTVQVRKEGFLGIMVIYGKHAEVGSGIFIS 406
                           ..||||.:.     |:|.|...|...:|...|.:.:...:.|:
Human   222 ---------------GGDETKLLVVDRETDEFFKKCRVIPSQEHLNGPLPVPFTNGEI------- 264

  Fly   407 DLREGSNAELAGVKVGD----MLLAVNQDVTLESNYDD--------ATGLLKRAEGVVTM-ILLT 458
             .:|.|...||...:..    ::.:.:.|.:.|.|..|        |......::.::.. |.|.
Human   265 -QKENSREALAEAALESPRPALVRSASSDTSEELNSQDSPPKQDSTAPSSTSSSDPILDFNISLA 328

  Fly   459 LKSEEAIKAEKAAEEKKKEEAKKEE 483
            :..|.|.:...:....:.:.:||.|
Human   329 MAKERAHQKRSSKRAPQMDWSKKNE 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	26/87 (30%)
		PDZ_signaling	259..340	CDD:238492	19/80 (24%)
		PDZ_signaling	377..457	CDD:238492	14/92 (15%)
		PDZ_signaling	500..584	CDD:238492
		PDZ_signaling	597..672	CDD:238492
SLC9A3R1	NP_004243.1	PDZ_signaling	12..91	CDD:238492	28/102 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	114..192		20/151 (13%)
		PDZ_signaling	152..231	CDD:238492	27/163 (17%)
		EBP50_C	235..358	CDD:312529	23/127 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..358		12/77 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900