DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and MPDZ

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens

Alignment Length:	749	Identity:	195/749 - (26%)
Similarity:	320/749 - (42%)	Gaps:	162/749 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VTLDKTGKKSFGICIVRGE---VKDSPNTKTTGIFIKGIVPDSPAHLCGRLKVGDRILSLNGKDV 91
            |.|.:...||.||.||.|.   .:.|......|||||.::.||||...|.||.||||:.::|.|:
Human  1152 VELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDL 1216

  Fly    92 RNSTEQAVIDLIKEADFKIELEIQTFDKSDEQQAKSDPRSNGY----MQAKNKFNQEQTTNNNAS 152
            |:::.:..::.|::|...:...:|:......:........|.|    ..:.|.|......|.:.:
Human  1217 RDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLPSLLHNLYPKYNFSSTNPFADSLQINADKA 1281

  Fly   153 GGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASMRQKHSNYADEDDEDTRDMTGRIRTEAGYEI 217
            ..                  |...:.......:......|.:|:...:.|:....:|
Human  1282 PS------------------QSESEPEKAPLCSVPPPPPSAFAEMGSDHTQSSASKI-------- 1320

  Fly   218 DRASAGNCKLNKQEKDRDKEQEDEFGYTMAKINKRYNMMK-DLRRIEVQRDASKPLGLALAGHKD 281
                           .:|.::||||||:...|.:||..:. :|..||:::..| .|||:|||:||
Human  1321 ---------------SQDVDKEDEFGYSWKNIRERYGTLTGELHMIELEKGHS-GLGLSLAGNKD 1369

  Fly   282 RQKMACFVAGVDPNGALGSVDIKPG-----DEIVEVNGNVLKNRCHLNASAVFKNVDGD-KLVMI 340
            |.:|:.|:.|:|||||.|    |.|     ||::|:||.:|..|.|.|||::.|..... |::.|
Human  1370 RSRMSVFIVGIDPNGAAG----KDGRLQIADELLEINGQILYGRSHQNASSIIKCAPSKVKIIFI 1430

  Fly   341 TSRRKPNDEGMC----VKPIKKFPTASD--ETKFI----FDQFPKAR--------------TVQV 381
            .::...|...:|    |:|:   |:.|:  :.|.:    |..:.|.|              .||:
Human  1431 RNKDAVNQMAVCPGNAVEPL---PSNSENLQNKELGYHRFSLYSKPRQSSSHLVYLCSQLIAVQL 1492

  Fly   382 ----------------------------RKEGFLGIMVIYGKHAEVGSGIFISDLREGSNAELAG 418
                                        :.:|.|||.:   ...:..||:.|..|.|...|...|
Human  1493 HLTEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAI---SEEDTLSGVIIKSLTEHGVAATDG 1554

  Fly   419 -VKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSE----EAIKAEKAAEEKKKEE 478
             :||||.:|||:.::.:....:....|||.|:..|.   ||:.:|    :|:.:...|...:|:.
Human  1555 RLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVK---LTIHAENPDSQAVPSAAGAASGEKKN 1616

  Fly   479 AKKEEEKPQ-----------------------EPATAEIKPNKKILIELKVEKKPMGVIVCGGKN 520
            :.:....||                       :|||..|.|..:..||:...:..:|:.:.||.:
Human  1617 SSQSLMVPQSGSPEPESIRNTSRSSTPAIFASDPATCPIIPGCETTIEISKGRTGLGLSIVGGSD 1681

  Fly   521 NHVTTGCVITH-VYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKVHQLFHTTYEKAVTLTV 584
              ...|.:|.| ||.||....|.||...|.|.::||  |.:...|..:...:...|.:: |.||:
Human  1682 --TLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNG--IDLRKATHDEAINVLRQTPQR-VRLTL 1741

  Fly   585 FRADPPELEK-----FNVDLMKKAGKELGLSL--SPNEIGCTIADLIQGQYPEIDSKLQRGDIIT 642
            :|.:.|..|:     ..::|.||.||.||||:  ..|:.|..::|:::|...:.|.:|.:||.|.
Human  1742 YRDEAPYKEEEVCDTLTIELQKKPGKGLGLSIVGKRNDTGVFVSDIVKGGIADADGRLMQGDQIL 1806

  Fly   643 KFNGDALEGLPFQVCYALFKGANGKVSMEVTRPK 676
            ..||:.:.....:...||.|.:.|.|::||.|.|
Human  1807 MVNGEDVRNATQEAVAALLKCSLGTVTLEVGRIK 1840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492	31/87 (36%)
		PDZ_signaling	259..340	CDD:238492	37/86 (43%)
		PDZ_signaling	377..457	CDD:238492	26/122 (21%)
		PDZ_signaling	500..584	CDD:238492	24/84 (29%)
		PDZ_signaling	597..672	CDD:238492	25/76 (33%)
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492
		L27_2	6..63	CDD:312549
		PDZ_signaling	139..221	CDD:238492
		PDZ_signaling	257..334	CDD:238492
		PDZ	374..463	CDD:214570
		PDZ_signaling	560..629	CDD:238492
		PDZ_signaling	698..784	CDD:238492
		PDZ_signaling	1006..1076	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140
		PDZ_signaling	1149..1240	CDD:238492	31/87 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324		5/86 (6%)
		PDZ	1347..1433	CDD:214570	38/90 (42%)
		PDZ_signaling	1514..1593	CDD:238492	24/84 (29%)
		MPDZ_u10	1595..1659	CDD:374710	11/63 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645		5/44 (11%)
		PDZ	1660..1744	CDD:214570	25/88 (28%)
		PDZ_signaling	1758..1836	CDD:238492	25/77 (32%)
		PDZ_signaling	1893..1978	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9829
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1419918at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103252
Panther	1	1.100	-	-	O	PTHR19964
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.820