DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaD and Pard3

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_112514.1	Gene:	Pard3 / 81918	RGDID:	620374	Length:	1337	Species:	Rattus norvegicus

Alignment Length:	557	Identity:	115/557 - (20%)
Similarity:	200/557 - (35%)	Gaps:	153/557 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   127 SDPRSNGYMQ--AKNKFNQEQTTNNNASGGQGMGQGQGQGQGMAGMNRQQSMQKRNTTFTASM-- 187
            |||...|...  :.|.|:.|:.:..|.:          :....||      ..|:|||.:...
  Rat   144 SDPALTGLSTSVSDNNFSSEEPSRKNPT----------RWSTTAG------FLKQNTTGSPKTCD 192

  Fly   188 RQKHSNY-------ADEDDEDTRDMTGRIRTEAGYE-IDRASAGNCKLNKQEKDRDKEQEDE--- 241
            |:|..||       :...::..|| ..|....|.:. :||      .|.|||:|.:..:||.
  Rat   193 RKKDENYRSLPRDPSSWSNQFQRD-NARSSLSASHPMVDR------WLEKQEQDEEGTEEDSSRV 250

  Fly   242 --FGYTMAKINKRYNMMKD--LRRIEVQRDASKPLGLALAGHKDR--QKMACFVAGVDPNGALGS 300
              .|:....:....|...|  ::.::|..|.. |||:.:.....|  :.:...|..::..|....
  Rat   251 EPVGHADTGLENMPNFSLDDMVKLVQVPNDGG-PLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQ 314

  Fly   301 VDI-KPGDEIVEVNGNVLKNRCHLNASAVFKNVDGDKLVMI-------------TSRRKPND--- 348
            .:: ...|.||.:|...|:||....|..:|:.....:::..             .|:|:.|:
  Rat   315 ENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRARVIWFHVVPAANKEQYEQLSQREMNNYSP 379

  Fly   349 -----EGMCV----------------------------------------KPIKKFPTA------ 362
                 :..||                                        ||    |||
  Rat   380 GRFSPDSHCVANRSVANNAPQALPRAPRLSQPPEQLDAHPRLPHSAHASTKP----PTAPALAPP 440

  Fly   363 ---SDETKFIFD--QFPKARTVQVRK--EGFLGIMVIYGKHAEVGSG--IFISD-LREGSNAELA 417
               |.....:::  :..|...:|::|  || ||.. |..:...:|..  |::.: |..|:..:..
  Rat   441 NVLSTSVGSVYNTKRVGKRLNIQLKKGTEG-LGFS-ITSRDVTIGGSAPIYVKNILPRGAAIQDG 503

  Fly   418 GVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEA-----IKAEKAAEEKKKE 477
            .:|.||.|:.||.......:.::...||:..:...|:.||..:.|||     :.||.:..:..||
  Rat   504 RLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEEAFHPREMNAEPSQMQSPKE 568

  Fly   478 EAKKEE------EKPQEPATAEIKPNKKILIELKVEKKPMGVIVCG--GKNNHVTTGCVITHVYP 534
            ...::|      :..:|..|.|:..|..       ....:||.|.|  .|.||...|..:..:..
  Rat   569 TKAEDEDIVLTPDGTREFLTFEVPLNDS-------GSAGLGVSVKGNRSKENHADLGIFVKSIIN 626

  Fly   535 EGQVAADKRLKIFDHICDINGTPI----HVGSMTTLK 567
            .|..:.|.||::.|.:..:||..:    :..:|.||:
  Rat   627 GGAASKDGRLRVNDQLIAVNGESLLGKANQEAMETLR 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492	17/83 (20%)
		PDZ_signaling	377..457	CDD:238492	20/84 (24%)
		PDZ_signaling	500..584	CDD:238492	18/74 (24%)
		PDZ_signaling	597..672	CDD:238492
Pard3	NP_112514.1	DUF3534	1..146	CDD:288873	1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	81..109
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	143..263		32/141 (23%)
		PDZ_signaling	272..347	CDD:238492	17/75 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..441		5/47 (11%)
		PDZ_signaling	465..544	CDD:238492	20/80 (25%)
		PDZ_signaling	588..681	CDD:238492	21/83 (25%)
		Interaction with PRKCI and PRKCZ. /evidence=ECO:0000269\|PubMed:9763423	712..936
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..888
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..1015
		Interaction with FRMD4A. /evidence=ECO:0000250\|UniProtKB:Q99NH2	935..1337
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1028..1055
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1110..1271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1284..1337
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900