Protein Alignment inaD and NHERF4

DIOPT Version :10

• Sequence 1: NP_001246470.1
• Gene: inaD / 37629
• FlyBaseID: FBgn0001263
• Length: 686
• Species: Drosophila melanogaster
• Sequence 2: XP_011541303.1
• Gene: NHERF4 / 79849
• HGNCID: 19891
• Length: 571
• Species: Homo sapiens
• Alignment Length: 424
• Identity: 82/424 - (19%)
• Similarity: 144/424 - (33%)
• Gaps: 139/424 - (32%)

  Fly   355 PIKKFPTASDETKFIFDQFPKA----RTVQVRKEGFLGIMVI----------------------- 392
            |:...||....|:   .:.|..    |..|...|..||:..:
Human    56 PLPTNPTTQHPTR---QKLPSTLSGHRVCQAHGEPVLGLCPLLPLFCCPPHPPDPWSLERPRFCL 117

  Fly   393 --------YGKH--AEVG-SGIFISDLREGSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLK 446
                    :|.|  .|:| :|..:..:..|::|:..|::.||.:||||.||.   .::|...:::
Human   118 LSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVV---EHEDYAVVVR 179

  Fly   447 RAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEEKPQEPATAEIKPNKKILIELKVEKKPM 511
            |.......:|||:.:..|                      .:.|.|::..:..:...|....:|.
Human   180 RIRASSPRVLLTVLARHA----------------------HDVARAQLGEDAHLCPTLGPGVRPR 222

  Fly   512 GVIVCGGKNNHVTTGCVITH--------VYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKV 568
               :|....:....|..:||        |...|..|....:.....:.::||.     |:.....
Human   223 ---LCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGV-----SVEKFTH 279

  Fly   569 HQLFHTTYEKAVTLTVFRADPPELEKFNVDLMKKAGKELGLSLS--------------------- 612
            :||....::....:|:..|. ||:|        :..::|||.|:
Human   280 NQLTRKLWQSGQQVTLLVAG-PEVE--------EQCRQLGLPLAAPLAEGWALPTKPRCLHLEKG 335

  Fly   613 PNEIGCTI-----ADLIQGQY-----PEIDSK---LQRGDIITKFNGDALEGLPFQVCYALFKGA 664
            |...|..:     .|...||:     |.:.:|   :|.||.:....|:::|||..:...:..:|.
Human   336 PQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQ 400

  Fly   665 NGKVSMEVTRPK-----------PTL---RTEAP 684
            ...||:.|..|:           |.|   .||||
Human   401 GSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAP 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ1_INAD-like	29..115	CDD:467276
		PDZ8_MUPP1-PDZ7_PATJ-PDZ2_INAD-like	259..342	CDD:467160
		PDZ3_INAD-like	379..454	CDD:467277	22/108 (20%)
		PDZ4_INAD-like	501..585	CDD:467278	15/91 (16%)
		PDZ5_INAD-like	596..674	CDD:467279	22/111 (20%)
NHERF4	XP_011541303.1	PDZ_NHERF-like	114..193	CDD:467249	21/81 (26%)
		PDZ_NHERF-like	222..299	CDD:467249	13/84 (15%)
		PDZ_NHERF-like	328..410	CDD:467249	18/81 (22%)
		PDZ	475..544	CDD:214570