DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment inaD and PDZD3

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	XP_011541302.1	Gene:	PDZD3 / 79849	HGNCID:	19891	Length:	571	Species:	Homo sapiens

Alignment Length:	424	Identity:	82/424 - (19%)
Similarity:	144/424 - (33%)	Gaps:	139/424 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 PIKKFPTASDETKFIFDQFPKA----RTVQVRKEGFLGIMVI----------------------- 392
            |:...||....|:   .:.|..    |..|...|..||:..:
Human    56 PLPTNPTTQHPTR---QKLPSTLSGHRVCQAHGEPVLGLCPLLPLFCCPPHPPDPWSLERPRFCL 117

  Fly   393 --------YGKH--AEVG-SGIFISDLREGSNAELAGVKVGDMLLAVNQDVTLESNYDDATGLLK 446
                    :|.|  .|:| :|..:..:..|::|:..|::.||.:||||.||.   .::|...:::
Human   118 LSKEEGKSFGFHLQQELGRAGHVVCRVDPGTSAQRQGLQEGDRILAVNNDVV---EHEDYAVVVR 179

  Fly   447 RAEGVVTMILLTLKSEEAIKAEKAAEEKKKEEAKKEEEKPQEPATAEIKPNKKILIELKVEKKPM 511
            |.......:|||:.:..|                      .:.|.|::..:..:...|....:|.
Human   180 RIRASSPRVLLTVLARHA----------------------HDVARAQLGEDAHLCPTLGPGVRPR 222

  Fly   512 GVIVCGGKNNHVTTGCVITH--------VYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKV 568
               :|....:....|..:||        |...|..|....:.....:.::||.     |:.....
Human   223 ---LCHIVKDEGGFGFSVTHGNQGPFWLVLSTGGAAERAGVPPGARLLEVNGV-----SVEKFTH 279

  Fly   569 HQLFHTTYEKAVTLTVFRADPPELEKFNVDLMKKAGKELGLSLS--------------------- 612
            :||....::....:|:..|. ||:|        :..::|||.|:
Human   280 NQLTRKLWQSGQQVTLLVAG-PEVE--------EQCRQLGLPLAAPLAEGWALPTKPRCLHLEKG 335

  Fly   613 PNEIGCTI-----ADLIQGQY-----PEIDSK---LQRGDIITKFNGDALEGLPFQVCYALFKGA 664
            |...|..:     .|...||:     |.:.:|   :|.||.:....|:::|||..:...:..:|.
Human   336 PQGFGFLLREEKGLDGRPGQFLWEVDPGLPAKKAGMQAGDRLVAVAGESVEGLGHEETVSRIQGQ 400

  Fly   665 NGKVSMEVTRPK-----------PTL---RTEAP 684
            ...||:.|..|:           |.|   .||||
Human   401 GSCVSLTVVDPEADRFFSMVRLSPLLFLENTEAP 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492
		PDZ_signaling	377..457	CDD:238492	23/113 (20%)
		PDZ_signaling	500..584	CDD:238492	14/91 (15%)
		PDZ_signaling	597..672	CDD:238492	21/108 (19%)
PDZD3	XP_011541302.1	PDZ_signaling	113..193	CDD:238492	21/82 (26%)
		PDZ_signaling	221..298	CDD:238492	14/84 (17%)
		PDZ	326..411	CDD:214570	18/84 (21%)
		PDZ_signaling	466..545	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900