DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment inaD and Whrn

DIOPT Version :9

Sequence 1:	NP_001246470.1	Gene:	inaD / 37629	FlyBaseID:	FBgn0001263	Length:	686	Species:	Drosophila melanogaster
Sequence 2:	NP_001008791.1	Gene:	Whrn / 73750	MGIID:	2682003	Length:	918	Species:	Mus musculus

Alignment Length:	401	Identity:	86/401 - (21%)
Similarity:	146/401 - (36%)	Gaps:	107/401 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   258 DLRRIEVQR-DASKPLGLALAGHKDRQKMACFVAGVDPNGALGSVDIKPGDEIVEVNGNVLKNRC 321
            ::|.:.::| .|.:.||.::.|..: ..:..:|:.|:|........::.||:|:.||...|....
Mouse   138 EVRLVSLRRAKAHEGLGFSIRGGSE-HGVGIYVSLVEPGSLAEKEGLRVGDQILRVNDKSLARVT 201

  Fly   322 HLNASAVFKNVDGDKLVM--ITSRRKP------------NDEGMCVKPIKKFPTASDETKFIFDQ 372
            |..|....|.  ..|||:  .::.|.|            :.:|....|....|.
Mouse   202 HAEAVKALKG--SKKLVLSVYSAGRIPGGYVTNHIYTWVDPQGRSTSPPSSLPQ----------- 253

  Fly   373 FPKARTVQVRKEG------------------------FLGIMVIYGKHAEVGSGIFISDLREGSN 413
             |...|::.|::.                        .||:.:..|  ||.|.||:|:.:..||.
Mouse   254 -PHGSTLRQREDDRRSTLHLLQSGDEKKVNLVLGDGRSLGLTIRGG--AEYGLGIYITGVDPGSE 315

  Fly   414 AELAGVKVGDMLLAVNQDVTLESNYDDATGLLKRAEGVVTMILLTLKSEEAIKAEKAAEEKKKEE 478
            ||.:|:||||.:|.||....|...:|:|..|||.:.    .::||:|....:...:...::.|..
Mouse   316 AESSGLKVGDQILEVNGRSFLNILHDEAVKLLKSSR----HLILTVKDVGRLPHARTTVDQTKWI 376

  Fly   479 AKKE----------------EEKPQEPATAEIKPNKKILIELKVEKKPMGVIVCGGKNNHVTTGC 527
            |...                ||...:|.               ..|.|.|..|......:.|...
Mouse   377 ASSRIGESVANSAGFPGDHTEEGTSKPG---------------FYKGPAGSQVTLSSLGNQTRAL 426

  Fly   528 V---ITHVYPEGQVAADKRLKIFDHICDINGTPIHVGSMTTLKVHQLFH--TTYEKAVTLTVFRA 587
            :   ..|:..|     .:|..:..::....|..|.|.:|    |..||.  .|:.|...|:..|:
Mouse   427 LDDQARHLLTE-----QERATMMYYLAQYRGGTISVEAM----VMALFELLNTHAKFSLLSEVRS 482

  Fly   588 --DPPELEKFN 596
              .|.:|::|:
Mouse   483 IISPQDLDRFD 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
inaD	NP_001246470.1	PDZ_signaling	27..115	CDD:238492
		PDZ_signaling	259..340	CDD:238492	21/83 (25%)
		PDZ_signaling	377..457	CDD:238492	29/103 (28%)
		PDZ_signaling	500..584	CDD:238492	18/88 (20%)
		PDZ_signaling	597..672	CDD:238492	86/401 (21%)
Whrn	NP_001008791.1	HN_L-whirlin_R1_like	38..113	CDD:259822
		PDZ_signaling	139..216	CDD:238492	19/79 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..266		6/37 (16%)
		PDZ_signaling	278..358	CDD:238492	29/85 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	387..407		3/34 (9%)
		HN_L-whirlin_R2_like	420..500	CDD:259823	18/83 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	503..538
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	560..824
		PDZ_signaling	827..898	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3528
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900